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Response of children with short stature to recombinant human growth hormone (rhGH) after the first year of therapy

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Rajaa Jabbar kadhum¹*

 
 
 
Abstract

Short stature is the commonest cause of referral to a pediatric endocrine unit. The primary goal of rhGH therapy is attaining normal adult height. The objective of this study is to determine the response of children with short stature to rhGH after one year of therapy. The study were done on 110 children with short stature, their age range was 3-14 years they received regular rhGH in a dose of 0.24-0.3 mg/kg/week and their response were followed during the first year of therapy by bone age, anthropometric measurements & height velocity. Growth hormone deficiency was the leading cause of short stature contributing to 84.5%. There was  significant increase in mean height velocity after one year of rhGH therapy (7.1±3.5cm per year) which is almost the double of pretreatment height velocity. The catch up growth was slow in the first 6 months of therapy and there was significant increase in bone age at the end of the first year. The lowest response in mean height velocity was in prepubertal children 3-5 years of age (1.54±0.44 cm per year). We conclude that the growth was slow during the first six months but there was significant growth at the end of the first year of therapy with doubling of the height velocity & significant increase in bone age. The response was slow in the prepubertal age.

Keywords: Response; Short stature; rhGH; Height measurements; Height velocity

Copyright © 2017 by The American Society for BioMedicine and BM-Publisher, Inc.

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Case Report
DOI: http://dx.doi.org/10.18081/2333-5106/017-3/125-131
American Journal of BioMedicine Volume 5, Issue 3, pages 125-131
Received December 07, 2016; accepted February 11, 2017; published March 15, 2017

How to cite this article
kadhum RJ. Response of children with short stature to recombinant human growth hormone (rhGH) after the first year of therapy" style. American Journal of BioMedicine 2017;5(3):125-131.

Article outline
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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