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Effect of Sitagliptin on glycemic profiles and their correlation with PASI score in patients with plaque psoriasis

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Sarmad Nory Gany¹, Naseer N al Harchan², Muhsin Abdulhussein Al-Dhalimi³, Najah R Hadi*¹mail of corresponding author

 

Abstract

Psoriatic patients with plaque psoriasis particularly those with high body mass index have increasing risk of developing a diabetes mellitus type 2 (DM). Since both conditions are associated with dysregulation in DPP-IV, DPP-IV inhibitors have been suggested as therapeutic drugs for both diseases. The role of enzyme in the diabetes pathogenesis is well-known; however information on psoriatic patients is conflicting. The objective of this study is  to determine the effect of Sitagliptin on glycemic profiles and their correlation with PASI score in psoriatic patients with DM. The study was conducted on 50 diabetic patients with moderate to severe plaque psoriasis who were divided into two groups: Placebo group (n =25) Patients were administered placebo 100mg once daily plus dietary control and exercise for 3 months ; Sitagliptin group (n =25) Patients were administered Sitagliptin tablet 100mg  once a day plus dietary control and exercise for 3 months. PASI score for all patients was assessed before and after 12 weeks of treatment. The blood samples were obtained from the patients in both groups at baseline and after 12 week of therapy were used to measure the concentration of serum fasting blood sugar and HbA1c. Compared with baseline in Sitagliptin group and control group after 12 week, the level of fasting blood sugar, HbA1c, were significantly reduced and correlated with PASI score after 12 week of sitagliptin  treatment (P < 0.05). The current results reveal that sitagliptin improves psoriasis possibly via a reduction in glycemic profiles  which were significantly correlated with PASI score.

Keywords: Psoriasis; Diabetes; Sitagliptin; PASI score; Correlation

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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References

  1. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med 2009;361:496-509. [PubMed]
  2. Langan SM, Seminara NM, Shin DB, et al. Prevalence of metabolic syndrome in patients with psoriasis: A population-basedstudy in the United Kingdom. J Invest Dermatol 2012;132(3):556-562. [PubMed]
  3. Maria Dalamaga, Evangelia Papadavid. Metabolic comorbidities and psoriasis: The chicken or the egg? World J Dermatol 2013;2(4):32-35. [PubMed]
  4. Huang YH, Yang LC, Hui RY, et al. Relationships between obesity and the clinical severity of psoriasis in Taiwan. J Eur Acad Dermatol Venereol 2010;24(9):1035-1039. [PubMed]
  5. Duarte GV, Oliveira Mde F, Cardoso TM, et al. Association between obesity measured by different parameters and severity of psoriasis. Int. J Dermatol 2013;52(2):177-181. [PubMed]
  6. Farley E, Menter A. Psoriasis: comorbidities and associations. G Ital Dermatol Venereol 2011;146(1):9-15. [PubMed]
  7. Curat CA, Wegner V, Sengenès C, et al. Macrophages in human visceral adipose tissue:increased accumulation in obesity and a source of resistin and visfatin. Diabetologia 2006;49(4):744-747. [PubMed]
  8. Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation and insulin resistance. Eur Cytokine Netw 2006;17(1):4-12. [PubMed]
  9. Gallwitz B. Sitagliptin: Profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes. Drugs Today Barc 2007;43:13-25. [PubMed]
  10.  Nishioka A, Shinohara M, Tanimoto N. Sitagliptin, a Dipeptidyl Peptidase-IV Inhibitor, improves Psoriasis. Dermatology 2012;224:20-21. [PubMed]
  11. Ansorge S, Nordhoff K, Bank U, et al. Novel aspects of cellular action of dipeptidyl peptidase IV/CD26. Biol Chem 2011; 392:153-168. [PubMed]
  12. Drucker DJ, Rosen CF. Glucagon-like peptide-1(GLP-1) receptor agonists, obesity and  psoriasis: diabetes meet dermatology. Diabetologia 2011;54:2741. [PubMed]
  13. Mas-Vidal A1, Santos-Juanes J, Esteve-Martinez A. Psoriasiform eruption triggered by a dipeptidyl peptidase IV inhibitor. Dermatology 2012;224(1):20-1. [PubMed]
  14. Lynch M, Ahem TB, Timoney I, et al. DPP-4 inhibition and narrow-band ultraviolet-B light in psoriasis (dinup): study protocol for a randomized controlled trial. Trials 2016;17:29. [Abstract/Full-Text]
  15. Drucker DJ and Rosen CF. Glucagon-like peptide-1(GLP-1) receptor agonists, obesity and  psoriasis: diabetes meet dermatology. Diabetologia 2011;54:2741. [PubMed]
  16. Mas-Vidal A, Santos-Juanes J, Esteve-Martinez A. Psoriasiform eruption triggered by a dipeptidyl peptidase IV inhibitor. Dermatology 2012;224(1):20-1. [PubMed]
  17. Hamminga EA, van derLely AJ, Neumann HA, et al. Chronic inflammation in psoriasis and obesity: implications for therapy. Medical hypotheses 2006;67(4):768-73. [PubMed]
  18. Faurschou A, Pedersen J, Gyldenløve M, et al. Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques. Exp Dermatol 2013;22(2):150-2. [PubMed]
  19. Lynch M, Tobin AM, Ahern T, O'Shea D, Kirby B. Sitagliptin for severe psoriasis. Clinical and experimental dermatology 2014;39(7):841-2. [PubMed]
  20. Buysschaert M, Tennstedt D, Preumont V. Improvement of psoriasis during exenatide treatment in a patient with diabetes. Diabetes and metabolism 2012;38(1):86-8. [PubMed]
  21. Faurschou A, Gyldenlove M, Rohde U, et al. Lack of effect of the glucagon-like peptide-1 receptor agonist liraglutide on psoriasis in glucose-tolerant patients - a randomized placebo-controlled trial. J Eur Acad Dermatol Venereol 2015;29(3):555-9. [PubMed]
  22. Faurschou A, Knop FK, Thyssen JP, Zachariae C, Skov L, Vilsboll T. Improvement in psoriasis after treatment with the glucagon-like peptide-1 receptor agonist liraglutide. Acta diabetologica 2014;51(1):147-50. [PubMed]
  23. Yamaguchi K, Higashiura K, Ura N, et al. The effect of tumor necrosis factor-alpha on tissue specificity and selectivity to insulin signaling. Hyperten Res 2003;26:389-396. [PubMed]
  24. Cai D, Yuan M, Frantz F, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappa B. Nat Med 2005;11:183-190. [PubMed]
  25. Miossec P, Kolls JK. Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov 2012;11:763. [PubMed]
  26. Cordiali-Fei P, Bianchi L, Bonifati C, et al. Immunological biomarkers for clinical and therapeutic management of psoriasis. Mediators Inflamm 2014;236060. [PubMed]
  27. Lamharzi N1, Renard CB, Kramer F, et al. Hyperlipidemia in concert with  hyperglycemia stimulates the proliferation of macrophages in  atherosclerotic lesions: potential role of glucose-oxidized LDL. Diabetes 2004;53(12):3217-25. [PubMed]
  28. Gyldenløve M, Storgaard H, Holst JJ, Vilsbøll T, Knop FK, Skov L. Patients with psoriasis are insulin resistant. J Am Acad Dermatol2015;72(4):599-605. [PubMed]
  29. Derosa G, Ragonesi PD, Fogari E, et al. Sitagliptin added to previously taken antidiabetic agents on insulin resistance and lipid profile: a 2-year study evaluation. Fundam Clin Pharmacol 2014;28(2):221-9. [PubMed]
  30. Boehncke WH, Boehncke S and Buerger C. Beyond  immunopathogenesis. Insulin resistance and epidermal  dysfunction. Hautarzt 2012:63:178-83. [Abstract/Full-Text]
  31. Abbate SL, Brunzell JD. Pathophysiology of hyperlipidemia in diabetes mellitus. J Cardiovasc Pharmacol 1990;16:1-7. [PubMed]

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DOI: 10.18081/2333-5106/016-10/410-420

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Research Article
American Journal of BioMedicine Volume 4, Issue 10, pages 410-420
Received August 02, 2016; accepted September 21, 2016; published October 04, 2016

How to cite this article
Lee Y, Ballantyne C, Maynard JA. Old foreign body in vertebra: delayed symptoms. American Journal of BioMedicine 2016;4(10):410-420.

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