Ivor A. Benjamin¹, Toshio Higashi, Silvana Hrelia∗
Myocardial ischemia and reperfusion injury (I/R) is a common cause of myocardial injury following cardiac operations and intervention leading to an induction of oxidative stress, cellular dysfunction and depressed of cardiac function. DNA damage, including oxidative base modifications and physical DNA strand breaks, is a consequence of myocardial I/R. Like many other organs in the body, a redundant and highly conserved set of endogenous repair pathways have evolved to selectively recognize the various types of cellular DNA damage and combat its negative effects on cell viability. Severe damage to the DNA, however, can trigger cell death and elimination of the injured myocytes. In this study, we will organized the state of the current field of DNA damage and repair in the myocardium, and provide some expected and in some cases, unexpected results with regards to their response following myocardial I/R and could provide new opportunities for cardiac research.
Keywords: Myocardial ischemia/reperfusion; DNA damage; Cardiac function
Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.
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American Journal of BioMedicine Volume 4, Issue 11, pages 466-479
Received June 02, 2016; accepted October 19, 2016; published November 24, 2016
How to cite this article
Benjamin IA, Higashi T, Hrelia S. Potential role of DNA repair in myocardial injury following ischemia and reperfusion. American Journal of BioMedicine 2016;4(11):466-479.
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