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Critical role of high-mobility-group proteins in kidney development/cross-talk Wnt/β-catenin signaling pathway

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 Mary Ann S. Arndt¹, William D. Wheaton, William R. Welch, Didier Payen*  
Abstract
The treatment of severe acute kidney injury with dialytic support for renal replacement therapy can be life sustaining and permit recovery from critical illness.The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and reduced in the corresponding adult tissues. We used used in study C57BL/6, HMG+/− and HMG−/−  mice and found that HMG is expressed in the mouse embryonic kidney at the cortex area. HMG knockout led to enhanced Wnt/β-catenin signaling pathway. Analysis of siRNA-mediated loss-of-function experiments in embryonic kidney culture confirmed the role of HMG as a key regulator of cortex epithelium differentiation. Keywords: High-mobility-group; Wnt/β-catenin; Kidney < p style=\"text-align: justify;\">Copyright © 2017 by The American Society for BioMedicine and BM-Publisher, Inc. < p style=\"text-align: justify;\">
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Case Report
DOI: http://dx.doi.org/10.18081/2333-5106/017-4/207-222
American Journal of BioMedicine Volume 5, Issue 4, pages 207-222
Received January 21, 2017; accepted April 23, 2017; published April 30, 2017

How to cite this article
Arndt MS, Wheaton WD, Welch WR, Payen WE. Epidemiology of acute lung injury in patients with cerebrovascular accident: a retrospective study. American Journal of BioMedicine 2017;5(4):207-222.

Case report outline
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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