Nikolaos F. Giannakoulas, Enrique Speletas, vkaran Karanikas, Harold A. Damania
Abstract
Hepatosplenic T-cell lymphoma (HSTCL) is a rare, aggressive T- cell lymphoma that is characterized by hepatosplenic and bone marrow sinusoidal infiltration of cytotoxic T cells, usually of gamma-delta (γδ) T-cell receptor type. The diagnosis was challenging as he required an extensive investigation that ultimately showed the characteristic clinical, histopathologic, and cytogenetic features of hepatosplenic T-cell lymphoma. We report a case of 12-year-old girl patient with HSTCL and visceral leishmaniasis, presented with progressive jaundice, massive hepatosplenomegaly, and weight loss. The diagnosis was required an extensive investigation that ultimately revealed the characteristically clinical, histopathological and cytogenetic features of hepatosplenic T-Cell Lymphoma. The clinical course was aggressive and multi-agent chemotherapy are used. The importance of considering it in a differential diagnosis of hepatosplenomegaly in young girl who present with constitutional symptoms and visceral leishmaniasis without lymphadenopathy.
Keywords: HSTCL; Visceral leishmaniasis; Chemotherapy; Lymphadenopathy
Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.
1. Falchook GS, Vega F, Dang NH, et al. Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment. Ann Oncol 2009;20(6):1080–1085. [PubMed] [Cross Ref]
2. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES . The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical application. Blood 2011;117(19):5019-32.
3. Beigel F, Jurgens M, Tillack C, et al. Hepatosplenic T-cell lymphoma in a patient with Crohn’s disease. Nat Rev Gastroenterol Hepatol 2009;6(7):433–436. [PubMed] [Cross Ref]
4. Cardo LJ, Rentas FJ, Ketchum L, et al. Pathogen inactivation of Leishmania donovani infantum in plasma and platelet concentrates using riboflavin and ultraviolet light. Vox Sang. 2006;90(2):85-91. [PubMed]
5. Rubiano LC, Miranda MC, Muvdi Arenas S, et al. Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children. J Infect Dis. 2012;205(4):684-92. [PubMed]
6. Mohammad BI, Al Shammary MN, Abdul Mageed RH, Yousif NG. Herbal extract targets in Leishmania tropica. J Parasit Dis 2015;39(4):663-72.
7. Salhany KE, Feldman M, Kahn MJ, et al. Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation. Hum Pathol 1997;28(6):674-685. [PubMed] [Cross Ref]
8. Falchook GS, Vega F, Dang NH, et al. Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment. Ann Oncol 2009;20(6):1080-5. [PubMed]
9. Vose J, Armitage J, Weisenburger D. International T-Cell Lymphoma Project. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008;26(25):4124-4130. [Abstract/Full-Text]
10. Belhadj K, Reyes F, Farcet JP, et al. Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood. 2003;102(13):4261-4269. [PubMed] [Cross Ref]
11. Jonveaux P, Daniel MT, Martel V, Maarek O, Berger R. Isochromosome 7q and trisomy 8 are consistent primary, non-random chromosomal abnormalities associated with hepatosplenic T gamma/delta lymphoma. Leukemia 1996;10(9):1453-1455. [PubMed]
12. Francois A, Lesesve JF, Stamatoullas A, et al. Hepatosplenic gamma/delta T-cell lymphoma: a report of two cases in immunocompromised patients, associated with isochromosome 7q. Am J Surg Pathol 1997;21(7):781-790. [PubMed] [Cross Ref]
13. Mackey AC, Green L, Liang LC, et al. Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2007;44:265–7. [PubMed]
14. Lai R, Larratt LM, Etches W, et al. Hepatosplenic T-cell lymphoma of alphabeta lineage in a 16-year-old boy presenting with hemolytic anemia and thrombocytopenia. Am J Surg Pathol 2000;24(3):459-63. [PubMed]
15. Macon WR, Levy NB, Kurtin PJ, et al. Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas. Am J Surg Pathol. 2001;25(3):285–296. [PubMed] [Cross Ref]
READ THE FULL ARTICLE
1. Access this article through your login credentials or your institution
2. Access this article through OpenAthens/Sign in
3. Purchase this article at rate $55.00 and received Full-Text/PDF
For any technique error please contact us and will be response to sending purchase article by email.
Thank you for visiting American Journal of BioMedicine. * = Required fields
[gravityform id=”6″ name=”Feedback”]
References
You will have online immediate access to article following the completion of this purchase and you may download and print a copy of each article for your personal use. Use the coding below to purchase your article as PDF by credit card, debit card, payball will be asked to supply your billing card information. Before continue with your purchase please read carefully the AJBM terms and conditions of purchase.