Clinical and experimental evidence shows myocardial contractile depression develops 4-24 hrs post-burn. Although the pathogenesis responsible for burn-induced myocardial depression is not well known, the aim of study is to investigate the role of microRNA-34a (miR-34a) in myocardial injury following post-burn by targeting Notch signaling pathway. MicroRNAs (miRNAs) have emerged as novel regulators in various pathological processes, but the precise role of miRNAs in post burn-induced myocardial depression remains largely unknown, a model of burn procedure. The results showed that for the first time that MicroRNA-137 functionally regulates Notch signaling pathway to protect burn-induced myocardial injury. Therefore, dual targeting of both the MicroRNA-137 and Notch1 signaling axes may be a potential therapeutic avenue to inhibit the burn-induced myocardial injury.
Keywords: MicroRNA-137; Notch; Burn-induced myocardial depression
Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.
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American Journal of BioMedicine Volume 4, Issue 12, pages 543-552
Received July 13, 2016; accepted November 11, 2016; published December 16, 2016
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How to cite this article
Sambol J, Horton J, Chen H, Gonzales C, Faulkner J. MicroRNA-137 protects burn-induced myocardial depression via regulation of the Notch signaling pathway. American Journal of BioMedicine 2016;4(12):543-552.
4. Method and Materials