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Anti-inflammatory role of colchicine following hepatic ischemia and reperfusion

 
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doi:10.18081/2333-5106/015-08/481-493
American Journal of BioMedicine Volume 3, Issue 8, pages 481-493
Published: August 20, 2015


Yong Lee, Pavlos Jonthan, Jonathan Bower, Catharina Grulich, Jennifer Hollox, Sabin Scheetz

Abstract

Hepatic ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. This study investigates the effect of colchicine on hepatic ischemia induced by I/R of the mice liver. Mice C57 were divided into three groups as liver I/R control, 10 mg/kg colchicine + liver I/R, and healthy group. Malondialdehyde (MDA), total glutathione (GSH) levels and myeloperoxidase (MPO), and DNA damage product level results from liver tissues and serum AST and ALT levels were determined. The data obtained were compared with the results from the liver ischemia/reperfusion and sham operation groups.These experimental findings indicate that colchicine may be useful in the treatment of hepatic I/R damage.

Keywords: Hepatic ischemia-reperfusion; Inflammatory response; Colchicine; Oxidants

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