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Potential role of cytomegalovirus in risk factor of breast cancer

 
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Research Article 
dx.doi.org/10.18081/2333-5106/016-3/54-60
American Journal of BioMedicine Volume 4, Issue 3, pages 54-60
Received September 13, 2015; accepted February 10, 2016; published March 21, 2016

 Maitham Ghaly Yousif, Ph.D.mail of corresponding author

Abstract

It has been hypothesized that human cytomegalovirus (CMV) may be associated with many cancers in human. However, the role of CMV infection in breast cancer remains unclear. We aimed to assess whether CMV infection have a role in development of breast cancer. A 120 women presented to breast cancer clinic with breast mass. Full history from each woman was taken, full examination including breast examination and lymph-node. Blood was aspirated from each woman for detection of CMV IgG, IgM, tp53 and CA15-3 by ELISA. A 50 patients were documented to have breast cancer by histopathological examination. The study reveal that was heights level of CMV IgG and IgM among patients with malignant breast mass (12/50) and (8/50) respectively in other side the lowest level in benign tumor (6/50) and (2/50) respectively and high prevalence of CMV in breast cancer. In conclusion There is strong evidence suggest that CMV has an important role in the development of breast cancer.

Keywords: Cytomegalovirus Breast cancer ; Cancer

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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