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Critical levels of serum myeloperoxidase in patients with systemic lupus erythematosus

American Journal of BioMedicine  Volume 2, Issue 8, pages 1025-1037 September 2014


Yojirou Kishihara; Osamu Kawai; ArthurTakeuchi

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune and inflammatory disease characterized by the polyclonal activation of T and B lymphocytes, production of autoantibodies, and formation of immune complex. We measured the serum level of myeloperoxidase (MPO) in patients with SLE (n = 97) and in healthy controls (n = 88) and assessed the correlation between the serum myeloperoxidase (MPO) levels and established disease-activity indexes. All patient samples with SLE analyzed showed higher serum levels of MPO than healthy controls. Higher MPO levels were observed in SLE patients with increased C-reactive protein (P=0.001), as well as in those with highly active disease (P<0.005). Our concluded is that the associations between MPO and the disease variables of SLE patients support a role for MPO in the inflammatory process of the disease.

Keywords: Systemic lupus erythematosus; Myeloperoxidase; Immune complex; C-reactive protein


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