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Dose effects of cyclosporine and risk of cancer after heart transplantation

 

"Research Article"

American Journal of BioMedicine  Volume 3, Issue 2, pages 44-58, February 2015


Emily Jackson; Ju Song; Nayoung  Lee; David Viner; Rommel  Morgan; Siomar Statland; Anderson Bravo 

Abstract

Cyclosporine is a potent immunosuppressant medication that is considered a disease modifying antirheumatic drug (DMARD) and used as treatment options after heart transplantation to improved long-term survival rates. The increased incidence of cancer after heart transplantation is well established in the literature, yet outcome studies of quantitative dose of cyclosporin related to cancer remains unclear. This prospective study was conducted between 1998 and 2013 and is based on 102 patients who had previously received heart transplant. The study results indicate that the average patient age was 65 years and the interval between transplantation and the appearance of solid cancer was 4.5 years (P < 0.002; OR = 2.02; 95% CI [1.59–2.29], P < 0.0002). However, the current study does draw much-needed attention to concerns about overall immunosuppressant exposure and its relationship to long-term outcomes after solid organ transplantation to reduce future cancer risk and more research for alternative drug level monitoring are important.

Keywords: Cyclosporine; Cancer; Heart transplantation; Long-term outcomes


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