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Effect of prepubertal and postpubertal long-term exposure to the mild dose of soybean seeds on the tissue and function of thyroid gland in albino rat

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Research Article
dx.doi.org/10.18081/2333-5106/016-6/233-242
American Journal of BioMedicine Volume 4, Issue 6, pages 233-242
Received January 02, 2016; accepted May 02, 2016; published June 25, 2016

Siham M. Abdul-Ridha1, Abed H. Baraaj2, Salim R. Hamudi3mail of corresponding author

Abstract

The aim of this study is to investigate the effect of long-term exposure to the mild dose of soybean seeds on the tissue and some physiological parameters of the thyroid gland in the prepubertal and postpubertal life stages. Twenty four Sprague-Dawley albino male rats were divided into four groups (n=6); control rats at the prepubertal life stage; prepubertal rats treated with 20% soybean seeds of daily diet for 40 days after the weaning; normal control rats, at the postpubertal stage; and postpubertal rats, were treated with 20% soybean seeds. Morphmetrical, histological and physiological changes were examined. Consumption of  mild dose of soybean seeds along the prepubertal life stage showed significant decrease (P<0.05) in the height of follicular cell, significant increase (P<0.05) in the diameter of follicular lumen and ratio of cold follicles, slightly non-significant decline in (T3 and T4) hormones levels and significant increment (P<0.05) in body weight, while at postpuberty, long-term exposure for the same dose of soybean seeds showed significant increase in the height of follicular cell (P<0.05), significant decrease (P<0.05) in the diameter of follicular lumen and ratio of cold follicles caused hyperactivity of the thyroid, significant decline (P<0.05) in (T3 and T4) hormones levels and slightly non-significant increment (P<0.05) in body weight. We concluded that the long-term exposure to the mild dose of the soybean affect adversely the tissue and function of the thyroid at both life stages, pre- and postpuberty.

Keywords: Soybean seeds; Tissue; Function; Thyroid; Puberty

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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