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Immunohistochemical determination of estrogen and progesterone receptors in breast cancer: pathological correlation and prognostic indicators

 
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Research Article 
dx.doi.org/10.18081/2333-5106/014-12/1229-1239
American Journal of BioMedicine Volume 2, Issue 12, pages 1229-1239
Received September 02, 2014; accepted November 29, 2014; December 24, 2014

Ali Hassan AI-Timimi amail of corresponding author, Nasser GhalyYousif b, c

Abstract

Carcinoma of the breast is the most common malignancy of women globally and the incidence has more risen in recent years. The current study was conducted with the objective of assessing estrogen receptor (ER) and progesterone receptor (PR) reactivity patterns of mammary cancers and to evaluate their association with clinicopathological features. A total of 61 cases of breast carcinoma were examined retrospectively using immunostains for estrogen receptor (ER) and progesterone receptor (PR). Staining pattern and intensity were correlated with histological subtypes and nuclear grades of tumors. The left breast was more commonly involved (57%) and tumor size ranged from 0.5-13.0cm. The predominant morphology was infiltrating ductal carcinoma (85.3%). The majority of the cases presented as grade II (55.3%) lesions with tumor necrosis (70%) and lymph node involvement (71.3%(. Positive nuclear staining for ER and PR was observed in 70.5% and 57.5%  of invasive carcinomas, respectively. In ER+ cases, fifty five cases (90%) gave diffuse immunohistochemical reaction for ER; In the remaining 10%, a focal ER reaction was seen. In PR+ cases, 49 cases (80%) gave diffuse immunohistochemical reaction for PR and In remaining 20% of PR+ tumors, the reaction was heterogeneous. In ductal infiltrative carcinomas the percentage of cases showed ER+ nuclear labeling is higher than those in cases of infiltrative lobular carcinomas. Assessment of ER and PR as prognostic markers for the clinical management of breast cancer patients is strongly advocated to provide best therapeutic options.

Keywords: Breast cancer; Estrogen receptor (ER); Progesterone receptor; Immunohistochemical reaction; Prognostic markers

Copyright © 2014 by The American Society for BioMedicine and BM-Publisher, Inc.

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