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In vitro evaluation of protoscolicidal effects of cetrimide and povidone-iodine in hydatid cyst disease

 
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Research Article  
dx.doi.org/10.18081/2333-5106/016-1/11-18
American Journal of BioMedicine Volume 4, Issue 1, pages 11-18
Received August 30, 2015; accepted December 03, 2015; published January 11, 2016 

Hassan Abdulla Abadi AL- Aqulia mail of corresponding author

Abstract

Echinococcosis is an endemic zoonotic disease caused by the dog tape-worm Echinococcus granulosus. Surgical treatment and percutaneous drainage have been used for the treatment of hydatid cysts. However, inactivation of the parasite with protoscolicidal agents is a crucial part in the treatment in both methods. The aim of this study was to evaluate the protoscolicidal effect of cetrimide and povidone-iodine in hydatid cyst disease. Fifty intact cysts of pulmonary hydatid disease of patients not received preoperative antihelmenthic were included in the study. While those cysts of patients who received preoperative antihelmenthic were excluded from the study. The protoscolicidal effect of cetrimide (0.05%, 0.1%, 0.5%) and povidone-iodine (10%) were assessed in this in vitro study using 1, 2 and 5 minutes as exposure time. Cetrimide (0.1%, 0.5%) have a higher protoscolicidal effect than 10% povidone-iodine that is statistically significant after different exposure time. The data concluded that cetrimide (0.1%) is a very effective protoscolicidal agent even with short exposure time, so it is the least concentration dependent and the least time dependent to achieve its protoscolicidal effect.

Keywords: Hydatid cyst; Viability; Protoscolicidal agents

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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