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Over-expression of miR-486/miR-150 in sepsis: marker in myocardial depression function

 
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doi: 10.18081/2333-5106/015-06/313-324
American Journal of BioMedicine Volume 3, Issue 6, pages 313-324
Published: June 20, 2015

Robert Thron, Thomas Andersson, Kay Lee, Malloy Adrienne

Abstract

Numerous biomarkers have been studied to identify the cause and severity of sepsis MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate the expression of genes by repressing translation or degrading mRNA. Sepsis is a life-threatening condition and the major cause of mortality among patients in intensive care units, including acute phase proteins such as C-reactive protein (CRP). However, the lack of specifity of these more frequently used biomarkers impedes the significant requirement to identify novel biomarkers for early sepsis detection. The role of miR-146a in the physiopathology of sepsis in myocardial depression continues to be poorly understood. miR-486/miR-150 may be used as a potential marker to difference sepsis induces myocardail function from non-sepsis causes.

Keywords: Myocardial depression; Biomarkers; mRNA; Sepsis


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