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Prevalence and factors associated with paroxysmal nocturnal hemoglobinuria presenting during pregnancy

 
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Research Article  
dx.doi.org/10.18081/2333-5106/015-11/725-738
American Journal of BioMedicine Volume 3, Issue 11, pages 725-738
Received:June 25, 2015; accepted: October 02, 2015; published: November 24, 2015


 Xin Wua, Ying Kanga, Jun Zhaoa, Huan Guoa, Yu Xieb, Xi Fenga, Xuan Dinga, Kun Leea mail of corresponding author

Abstract

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare type of acquired hemolytic anemia affecting all hematopoietic cell types. The abnormality of red blood cells in this disease predisposes to intravascular complement-mediated hemolysis. This study aimed to investigate PNH clone detection in pregnancy by the A fluorescein-labeled proaerolysin variant (FLAER) era. We have reviewed all pregnant and non-pregnant patients with a new diagnosis of PNH admitted between 2007 and 2014 in "First Affiliated Hospital of Xinjiang Medical University", China. Overall survival (OS) and event free survival (EFS) of the patients, and their relation with demographic and clinico-pathological factors have been analyzed.

Keywords: Paroxysmal Nocturnal Hemoglobinuria; Anemia; PNH; Hemolytic anemia

Copyright © 2015 by The American Society for BioMedicine and BM-Publisher, Inc.

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