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Regulatory mechanisms of IL-13 signaling pathway/role in normal gestation

 
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doi: 10.18081/2333-5106/015-08/468-480
American Journal of BioMedicine Volume 3, Issue 8, pages 468-480
Published: August 17, 2015


Marchil Carden, Maria Granger, Marchil G. Rovere, Amanda Bron, Jimmy Fukumoto

Abstract

It has become evident that IL-13 is a key mediator in the pathogenesis of many diseases. IL-13 receptors are expressed on human B cells, basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells. This review highlights the effector functions of IL-13 and describes multiple pathways for modulating its activity in fetal development during normal pregnancy.

Keywords: IL-13; Nnormal pregnancy; Fetal development; IL-4

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