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Role of IL-8 polymorphisms of gene in HIV patients in South Africa

 
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doi: 10.18081/2333-5106/015-05/220-231 
American Journal of BioMedicine Volume 3, Issue 5, pages 220-231
Published: 23 May 2015


Mark Fernandez Bedoya; Maria A. Hegeman; Marchil G. Rovere; Amanda Bron; Jimmy Fukumoto

Abstract

Interleukin-8 (IL-8) is one type of cytokine has a role in the regulation of the immune system. Cytokines have become the focus of many scientific studies, as there is evidence of the contribution of genetic factors to the imbalance of the inflammatory profile of the patient, which directly affects the clinical outcome and the severity of HIV. Recently demonstrated that IL-8 is produced by macrophages in response to HIV-1 and by endothelial cells in response to Kaposi's sarcoma-associated herpesvirus and that IL-8 plays an important role in the early angiogenesis of Kaposi's sarcoma. This study investigated the polymorphism of IL-8 gene among patients infected with HIV infection.

Keywords: Interleukin-8 (IL-8); Cytokine; HIV; Polymorphism


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