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Role of SMAD/TGF-β signalling pathway in connective tissue diseases

 
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Topic Review
dx.doi.org/10.18081/2333-5106/015-09/534-544
American Journal of BioMedicine Volume 3, Issue 9, pages 534-544
Published: September 10, 2015


Xiao Li, Michael Bronner, John A. Ribeiro, Karen Oliveira

Abstract

Several members of the TGF-β super family play important roles in connective tissue growth. The bone morphogenetic proteins (BMPs) induce early cartilage formation and MMP13 is a major enzyme targeting cartilage for the degradation of types II, IV, and IX collagen, proteoglycan, osteonectin and perlecan. In this review, we discuss the crosstalk between SMAD/TGF-β signalling pathway and therapeutic applications in connective tissue diseases.

Keywords:Connective tissue; TGF-β; BMP; MMP13; SMAD

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