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Study the association of human chorionic gonadotrophin in prediction of preeclampsia and its severity

 
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doi:10.18081/2333-5106/015-08/494-503
American Journal of BioMedicine Volume 3, Issue 8, pages 494-503
Published: August 22, 2015


Basima Sh.  Alghazali, Ashtha Farook Aboud

Abstract

The objective of this study is to evaluate the potential clinical use of maternal serum free human chorionic gonadotrophine (β-hCG) in prediction of preeclampsia and its severity. Two hundred and ten blood samples were collected from patients. Twenty seven patients were developed PE. These patients were followed for up to five months (first reading at 16-20 week, second reading at 21-28 week and third reading at 29-40 week). Patients suffered from any other disease were not included in the current study. The control group consisted of one hundred and eighty subjects. They were pregnant women without preeclampsia and other complications. These patients also were followed for up to five months (first reading at 16-20 week, second reading at 21-28 week and third reading at 29-40 week). Three patients were escaped. Compared with the control, The elevation of serum β-hCG was statistically significant, P value (<0.001) in women who were developed preeclampsia (mild and sever preeclampsia) later on throughout their pregnancy at 16-20, 21-28, and at 29-40 weeks of gestation, and there is further significant increment in the level of serum β-hCG in women who develop sever preeclampsia when compared with women who develop mild preeclampsia throughout their pregnancy, p value (<0.001). We are concluded that serum β-hCG is significantly associated with preeclampsia and they can be used as a markers for prediction of preeclampsia early in pregnancy and for evaluation of its severity.

Keywords: Preeclampsia; β-hCG; Pregnancy

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