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Taurine attenuates inflammatory response following cerebral ischemia and reperfusion

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American Journal of BioMedicine  Volume 2, Issue 5, pages 542–554, May 2014


Yezi Xerri; Mark N Evans; Giorgio Inoue; Tennent K Hanley; Douglas L Hainz

Abstract

Taurine is a kind of endogenous free amino acid in tissue and a potent antioxidant agent its function may in part be to adjust calcium homeostasis in cells, anti-oxidative stress, anti-inflammatory and cell protector but little is known about the expression or the role of Taurine in the central nervous system. Stroke is the major cause of death and disability worldwide. Here, we investigated the role of Taurine in ischemic stroke as a potential neuroprotective using rat model of transient cerebral ischemia. Transient cerebral ischemia was induced by MCAO were performed on male Sprague-Dawley rats. TTC staining used to measurement of infarct volume in the brain and ELISA kits to assay cytokines. Our data suggested that Taurine reduced cerebral infarct size, decreased pro-inflammatory cytokines expression and produced lower level of ICAM-1. These results suggest that Taurine can be exerting significantly protective effect against brain ischemic injury through inhibiting pro-inflammatory cytokines and ICAM-1.

Keywords: Strock; Taurine; Proinflammatroy cytokines; ICAM-1; Cerebral I/R


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