Gang Li, Wu Zhao,Tracey B Finn, Wilma Martin, Chris J Leung
A role for innate immunity in inflammation of CNS is being increasingly evidenced. This study focused on determining the role of toll-like receptor 4 (TLR4) and phosphorylation of MyD88/IRAK signaling pathway in systemic lupus erythematosus (SLE) pathogenesis. We used mouse models of SLE (BXSB/Yaa mice) and their controls (C57BL/6 mice). TLR4 significantly phosphorylation of MyD88/IRAK activity and enhanced SLE pathogenesis in BXSB/Yaa mice, whereas the small interference RNA-mediated knockdown of TLR4 activity attenuated SLE activity.
Keywords: TLR4; SLE; MyD88; IRAK
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