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TLR4-mediated Neuroinflammation in SLE through phosphorylation of MyD88/IRAK signaling pathway

 
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Research Article
dx.doi.org/10.18081/2333-5106/015-09/581-596
American Journal of BioMedicine Volume 3, Issue 9, pages 581-596
Published: September 29, 2015


Gang Li, Wu Zhao,Tracey B Finn, Wilma Martin, Chris J Leung

A role for innate immunity in inflammation of CNS is being increasingly evidenced. This study focused on determining the role of toll-like receptor 4 (TLR4) and phosphorylation of MyD88/IRAK signaling pathway in systemic lupus erythematosus (SLE) pathogenesis. We used mouse models of SLE (BXSB/Yaa mice) and their controls (C57BL/6 mice). TLR4 significantly phosphorylation of MyD88/IRAK activity and enhanced SLE pathogenesis in BXSB/Yaa mice, whereas the small interference RNA-mediated knockdown of TLR4 activity attenuated SLE activity.

Keywords: TLR4; SLE; MyD88; IRAK

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