Type 2 diabetes mellitus (T2DM) is a metabolic disorder and typically results from excess of caloric intake over energy expenditure. It is characterized by a progressive insulin secretory defect due to insulin resistance, which increases the body's demand for insulin in order to retain glucose homeostasis. Bariatric surgery is currently the only modality that provides a significant, sustained weight loss for morbidly obese patients, with resultant improvement in obesity-related comorbidities. The objective of this study is to investigate the effectiveness of gastric bypass in transgenic mice. The data showed that transgenic mice in gastric bypass group weighed remarkably less than sham group two weeks after surgery. Statistical analysis revealed that changes in body weight and FBG were significantly correlated. In conclusion, these resulted data demonstrate that gastric bypass surgery may be a potentially effective way to treat obesity-associated T2DM.
Keywords: Type 2 diabetes mellitus; Metabolic disorder; Transgenic mice
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- Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: A systematic review and meta-analysis. JAMA 2004;292(14):1724-37.
- Farzadfar F, Finucane MM, Danaei G, et al; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Cholesterol). National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 30 million participants. Lancet. 2011;377(9765):578-586.
- Tessier DJ, Eagon JC. Surgical management of morbid obesity. Curr Probl Surg. 2008;45(2):68-137.
- Angrisani L, Lorenzo M, Borrelli V. Laparoscopic adjustable gastric banding versus Roux-en-Y gastric bypass: 5-year results of a prospective randomized trial. Surg Obes Relat Dis. 2007;3(2):127-132, discussion 132-133.
- Varela JE. Laparoscopic sleeve gastrectomy versus laparoscopic adjustable gastric banding for the treatment severe obesity in high risk patients. JSLS. 2011;15(4):486-491.
- Miller JN, Colditz GA, Mosteller F. How study design affects outcomes in comparisons of therapy, II: surgical. Stat Med. 1989;8(4):455-466.
- Avsar FM, Ozel H, Topaloglu S, et al. Improvement of vertical banded gastroplasty by strict dietary management. Obes Surg. 2004;14(2):265-270.
- Lu G, Ades AE, Sutton AJ, Cooper NJ, Briggs AH, Caldwell DM. Meta-analysis of mixed treatment comparisons at multiple follow-up times. Stat Med. 2007;26(20):3681-3699.
- Sweeting MJ, Sutton AJ, Lambert PC. What to add to nothing? use and avoidance of continuity corrections in meta-analysis of sparse data. Stat Med. 2004;23(9):1351-1375.
- Kindel TL, Yoder SM, Seeley RJ, D’Alessio DA, Tso P. Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, GotoKakizaki rat by a GLP-1 receptor-mediated mechanism. J Gastrointest Surg 2009; 13(10): 1762-72.
- Cohen RV, Schiavon CA, Pinheiro JS, Correa JL, Rubino F. Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with body mass index of 22-34 kg/m2: A report of 2 cases. Surg Obes Relat Dis 2007; 3(2): 195-7.
- Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: Systematic review and meta-analysis. Am J Med 2009; 122(3): 248-256.e5.
- Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346(21):1623–30.
- Allen RE, Hughes TD, Ng JL, et al. Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes. Theor Biol Med Model. 2013;10:45.
- Saeidi N, Meoli L, Nestoridi E, et al. Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science. 2013;341(6144):406–10.
- Zhang H, DiBaise JK, Zuccolo A, et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci U S A. 2009;106(7):2365–70.
- Panunzi S, De Gaetano A, Carnicelli A, et al. Predictors of remission of diabetes mellitus in severely obese individuals undergoing bariatric surgery: do BMI or procedure choice matter? A meta-analysis. Ann Surg. 2015;261(3):459–67.
- Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980, systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011;377(9765):557–67.
- Danaei G, Finucane MM, Lu Y, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980, systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011;378(9785):31–40.
- American Diabetes Association. Standards of medical care in diabetes-2015 abridged for primary care providers. Clin Diabetes. 2015;33(2):97–111.
- Ribaric G, Buchwald JN, McGlennon TW. Diabetes and weight in comparative studies of bariatric surgery vs conventional medical therapy: a systematic review and meta-analysis. Obes Surg. 2014;24(3):437–55.
- Kim MK, Kim W, Kwon HS, et al. Effects of bariatric surgery on metabolic and nutritional parameters in severely obese Korean patients with type 2 diabetes: a prospective 2-year follow up. J Diabetes Investig. 2014;5(2):221–7.
- Lakdawala M, Shaikh S, Bandukwala S, et al. Roux-en-Y gastric bypass stands the test of time: 5-year results in low body mass index (30–35 kg/m2) Indian patients with type 2 diabetes mellitus. Surg Obes Relat Dis. 2013;9(3):370–8.
- Ikramuddin S, Korner J, Lee WJ, et al. Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. JAMA. 2013;309(21):2240–9.
- Mingrone G, Panunzi S, De Gaetano A, et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med. 2012;366(17):1577–85.
- Prevention or delay of type 2 diabetes. Diabetes Care. 2015; 38(Suppl. 1):S31–2.
- Klein S, Fabbrini E, Patterson BW, et al. Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes. Obesity (Silver Spring) 2012; 20(6): 1266-72.
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American Journal of BioMedicine Volume 4, Issue 5, pages 103-110
Received December 22, 2015; accepted April 12, 2016; published May 04, 2016
How to cite this article
Pierce DA, Merone LG, Henok A, Barrat FM. Gastro-intestinal bypass surgery revers diabetic mellitus experimental mice model. American Journal of BioMedicine 2016;4(5):103-110.
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