Type 2 diabetes mellitus (T2DM) is a metabolic disorder and typically results from excess of caloric intake over energy expenditure. It is characterized by a progressive insulin secretory defect due to insulin resistance, which increases the body's demand for insulin in order to retain glucose homeostasis. Bariatric surgery is currently the only modality that provides a significant, sustained weight loss for morbidly obese patients, with resultant improvement in obesity-related comorbidities. The objective of this study is to investigate the effectiveness of gastric bypass in transgenic mice. The data showed that transgenic mice in gastric bypass group weighed remarkably less than sham group two weeks after surgery. Statistical analysis revealed that changes in body weight and FBG were significantly correlated. In conclusion, these resulted data demonstrate that gastric bypass surgery may be a potentially effective way to treat obesity-associated T2DM.
Keywords: Type 2 diabetes mellitus; Metabolic disorder; Transgenic mice
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American Journal of BioMedicine Volume 4, Issue 5, pages 103-110
Received December 22, 2015; accepted April 12, 2016; published May 04, 2016
How to cite this article
Pierce DA, Merone LG, Henok A, Barrat FM. Gastro-intestinal bypass surgery revers diabetic mellitus experimental mice model. American Journal of BioMedicine 2016;4(5):103-110.
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