Mesenchymal stem cells improve diabetic neuropathy in rat model

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Xiaokun Shi¹, Kangquan Shou, Shi-Hong Shi, Jung Han Lee*
Author Affiliations
∗Correspondence author: ¹Key Laboratory of Translational Medicine of Cell Therapy Technology of Yunnan Province, Kunming, Yunnan, China.

 
 
 
 
Abstract

Diabetic neuropathy is difficult to treat in-spite new compound of drugs and high risk for foot ulceration and may be limb amputation. So far, there is no satisfactory treatment protocol to prevent or cure these disorders. Diabetic neuropathy is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Mesenchymal stem cells (MSC) were isolated from the inguinal adipose tissue of rats, and a streptozotocin-induced diabetic mice model of diabetic neuropathy. This study showed that MSC significantly promoted the level of antioxidant and the expression of antiapoptotic proteins, while lowering the expression of apoptotic proteins. The  end results data showed evidence that stem cell therapy of diabetic nephropathy differentiated from adipose tissue stem cell (ADSC) is a feasible and inexpensive therapy.
Keywords: Diabetic neuropathy; Diabetes; Mesenchymal stem cell

Copyright © 2017 by The American Society for BioMedicine and BM-Publisher, Inc.

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Research Article
DOI: http://dx.doi.org/10.18081/2333-5106/017-3/132-145
American Journal of BioMedicine Volume 5, Issue 3, pages 132-145
Received December 11, 2016; accepted February 22, 2017; published March 18, 2017

How to cite this article
Shi X, Shou K, Shi SH, Lee J. Stem cells from diabetic patients improve diabetic neuropathy" style. American Journal of BioMedicine 2017;5(3):132-145.

Article outline
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References