RESEARCH ARTICLE
Open Access

Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats

Odangowei Inetiminebi Ogidi1, Pere-Ere Sarah Tobia2, Blessing Elohor Poripo3 ORCID 

1Department of Biochemistry, Faculty of Basic Medical Sciences, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria
2Department of Microbiology, Faculty of Science, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria
3Department of Human Physiology, Faculty of Basic Medical Sciences, Bayelsa Medical University Yenagoa, Bayelsa State, Nigeria
DOI: 10.18081/ajbm.2026.1.37

Publication History: Received 12 September 2025, Revised 31 December 2025, Accepted 30 January 2026, Available online 11 February 2026
Copyright: © 2026 Ogidi, et al. This is an open-access article under a Creative Commons license (CC BY 4.0).
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ABSTRACT

Background

Malaria, caused by Plasmodium berghei, leads to severe hematological alterations such as anemia, leukocytosis, and thrombocytopenia. Ficus sur, known for its anti-inflammatory and antioxidant properties, has been traditionally used for various ailments.

Objective
This research evaluated the hematological impacts of the ethanolic extract of Ficus sur in albino rats infected with P. berghei.

Methods

Thirty male albino rats (150–200g) were allocated into five groups (n=6). Group 1 (normal control) remained uninfected, but Groups 2–5 were infected with P. berghei (NK 65 strain). Group 2 (parasite control) received no intervention, whereas Groups 3–5 were administered treatments from days 4 to 8 with the ethanolic extract of Ficus sur at dosages of 400 mg/kg (high dose), 200 mg/kg (low dose), and 10 mg/kg of chloroquine, respectively. Hematological parameters, including RBC, WBC, PCV, Hb, platelets, and WBC differential counts, were analyzed on days 4 and 8 post-infection using standard hematological methods.

Results

By day 4, the N.C. group had the highest RBC (6.14±0.05), PCV (69.95±0.62), Hb (17.96±0.33), and Platelets (4.36±0.03), while P.C. had the lowest RBC (2.84±0.06), PCV (32.54±1.10), Hb (7.58±0.27), and Platelets (3.35±0.04) but the highest WBC (14.41±0.18), neutrophils (26.70±0.70), and lymphocytes (80.66±0.87). By day 8, P.C. RBC dropped further (2.62±0.05), PCV (25.61±0.69), and Hb (5.36±0.22), while N.C. and S.C. maintained high RBC and platelets (~4.32–4.35).

Conclusion

The ethanolic extract of Ficus sur improved RBC indices and modulated WBC differentials, suggesting its potential as an adjunct therapy for malaria-induced hematological disorders.

Keywords: Arteriov Ficus sur; Plasmodium berghei; Anemia; Hematological; Malaria; Leukocytosis

Recommended Citation

Ogidi OI, PTobia PS, Poripo BE. Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats. Advanced Journal of Biomedicine & Medicine. 2026;14(1):37-56. doi:10.18081/ajbm.2026.1.37

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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2026 Vol 14, Issue 1 Pages 37-56

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Kim M, Lee S (2026). Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> . Advanced Journal of Biomedicine & Medicine, 14(1), 37-56. https://doi.org/10.18081/ajbm.2026.1.37
Kim M, Lee S. "Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> ." Advanced Journal of Biomedicine & Medicine, vol. 14, no. 1, 2026, pp. 37-56. DOI: 10.18081/ajbm.2026.1.37.
Kim M, Lee S. Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> . AJBM. 2026;14(1):37-56. DOI: 10.18081/ajbm.2026.1.37. PMID: .
Kim M, Lee S 2026, "Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> ", Advanced Journal of Biomedicine & Medicine, vol. 14, no. 1, pp. 37-56.
@article{kim2026, title={Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> }, author={Kim M, Lee S}, journal={Advanced Journal of Biomedicine & Medicine}, volume={14}, number={1}, pages={37-56}, year={2026}, doi={10.18081/ajbm.2026.1.37} }
TY - JOUR AU - Kim M, Lee S TI - Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> JO - American Journal of Biomedicine VL - 14 IS - 1 SP - 37-56 PY - 2026 DO - 10.18081/ajbm.2026.1.37 ER -
%0 Journal Article %A Kim M, Lee S %T Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> %J American Journal of Biomedicine %V 14 %N 1 %P 37-56 %D 2026 %R 10.18081/ajbm.2026.1.37 %M
Kim M, Lee S (2026). Hematological Evaluation of Ethanolic Extract of Ficus Sur in Plasmodium Berghei Infected Albino Rats<br /> . Advanced Journal of Biomedicine & Medicine, 14(1), 37-56. https://doi.org/10.18081/ajbm.2026.1.37

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