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Yan Xina, b, Howard D. Kirshnera, c, Carmen A. Peraltaa, Richard A. Ciavarraa
Abstract
IL-37 member suppresses inflammation among the various splicing forms of IL-37, IL-37b with unclear signaling pathway. Acute kidney injury resulted from ischemia and reperfusion is a significant clinical problem in cardiovascular medical and surgical procedures. In this study, we investigated the effects of IL-37b renal I/R injury in mice and to determine the involvement of nuclear factor kappa B (NF-kB) activation in the effects. Renal I/R was induced by right renal pedicle clamping for 45 min and left nephrectomy. Sham-operated mice with no occlusion of the renal vessel. I/R mice received an injection of recombinant IL-37b or vehicle, immediately before reperfusion. Compared with vehicle treatment, mice treated with recombinant IL-37b attenuates I/R-induced TNFα, IL-1β, and IL-6, inhibited the up-regulation of NF-kB activation after I/R with decreased the levels of plasma of both creatinine and urea. In conclusion; IL-37b exerts effects in vivo by modulating the NF-kB activation.
Keywords: IL37; Renal I/R; Cardiovascular diseases; Recombinant IL-37b
Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.
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