Anti-inflammatory role of colchicine following hepatic ischemia and reperfusion

 
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doi:10.18081/2333-5106/015-08/481-493
American Journal of BioMedicine Volume 3, Issue 8, pages 481-493
Published: August 20, 2015


Yong Lee, Pavlos Jonthan, Jonathan Bower, Catharina Grulich, Jennifer Hollox, Sabin Scheetz

Abstract

Hepatic ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. This study investigates the effect of colchicine on hepatic ischemia induced by I/R of the mice liver. Mice C57 were divided into three groups as liver I/R control, 10 mg/kg colchicine + liver I/R, and healthy group. Malondialdehyde (MDA), total glutathione (GSH) levels and myeloperoxidase (MPO), and DNA damage product level results from liver tissues and serum AST and ALT levels were determined. The data obtained were compared with the results from the liver ischemia/reperfusion and sham operation groups.These experimental findings indicate that colchicine may be useful in the treatment of hepatic I/R damage.

Keywords: Hepatic ischemia-reperfusion; Inflammatory response; Colchicine; Oxidants

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References

1. Glanemann M, Strenziok R, Kuntze R, et al. Ischemic preconditioning and methylprednisolone both equally reduce hepatic ischemia/reperfusion injury. Surgery 2004;135(2):203–214. [Abstract/Full-Text]

2. Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. Journal of Pathology 2000;190(3)255–266. [Abstract/Full-Text]

3. Demiryilmaz I, Turan MI, Kisaoglu A, Gulapoglu M, Yilmaz I, Suleyman H. Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels. Pharmacological Reports2014;66(4):647–652, 2014. [Abstract/Full-Text]

4. Jacob DH, Zeng IU, Tsung Y. Tpl2 exaggerated ischemic hepatic injury through induction of apoptosis: Downstream of caspase-9. American Journal of BioMedicine 2014; 2(4):422–439. [Abstract/Full-Text]

5. Hessheimer AJ, Fondevila C, Taurá P. et al. Decompression of the portal bed and twice-baseline portal inflow are necessary for the functional recovery of a “small-for-size” graft. Ann Surg 2011; 253:1201–1210. [PubMed]

6. Schlegel A, Rougemont O, Graf R, Clavien PA, Dutkowski P. Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts. J Hepatol 2013;58:278–286. [PubMed]

7. Schiesser M, Wittert A, Nieuwenhuijs VB, et al. Intermittent ischemia but not ischemic preconditioning is effective in restoring bile flow after ischemia reperfusion injury in the livers of aged rats. J Surg Res 2009;152:61–68. [PubMed]

8. Esposti DD, Domart MC, Sebagh M, Harper F, Pierron G,  Brenner C. et al.  Autophagy is induced by ischemic preconditioning in human livers formerly treated by chemotherapy to limit necrosis. Autophagy 2010;6:172–174. [PubMed]

9. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg  2001;181:160–166. [Abstract/Full-Text]

10. Sayarlioglu H, Dogan E, Erkoc R, et al. The effect of colchicine on the peritoneal membrane. Ren Fail 2006; 28:69–75. [PubMed]

11. Kershenobich D, Vargas F, Garcia-Tsao G, Perez Tamayo R, Gent M, Rojkind M. Colchicine in the treatment of cirrhosis of the liver. N Engl J Med 1988;318:1709–13. [PubMed]

12. Parsons CJ, Takashima M, Rippe RA. Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol 2007;22:79–84. [PubMed]

13. Zimmerman BJ, Granger DN. Reperfusion injury. Surgical Clinics of North America.1992;72(1):65–83. [PubMed]

14. Clemens MG. Nitric oxide in liver injury. Hepatology 1999;30:1–5. [PubMed]

15. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003;284: G15-G26. [PubMed]

16. Parmar KM, Larman HB, Dai G, et al. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest 2006;116: 49-58.

17. Bone RC, Sibbald WJ, and Sprung CL. The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 1992;101:1481–1483. [PubMed]

18. Jiang W, Sun R, Wei H, Tian Z. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc. Natl. Acad. Sci. USA. 2006;102:17077–17082. [PubMed]

19. Wornle M, Schmid H, Banas B, et al. Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am. J. Pathol 2006;168:370–385. [PubMed]

20. Tabiasco J, Devevre E, Rufer N, et al. Human effector CD8+ T lymphocytes express TLR3 as a functional coreceptor. J. Immunol 2006;177:8708–8713. [PubMed]

21. Ren F, Duan Z, Cheng Q, et al. Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism. Hepatology 2011;54:687–696. [PubMed]

22. Dumitru CD, Ceci JD, Tsatsanis C, et al. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 2000;103(7):1071–1083. [PubMed]

23. Fiorini RN, Shafizadeh SF, Polito C, et al. Anti-endotoxin monoclonal antibodies are protective against hepatic ischemia/reperfusion injury in steatotic mice. Am J Transplant 2004;4:1567–1573. [PubMed]

24. Bamboat ZM, Balachandran VP, Ocuin LM, Obaid H, Plitas G, DeMatteo RP. Toll-like receptor 9 inhibition confers protection from liver ischemiareperfusion injury. Hepatology 2009; 51:621–632. [PubMed]

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