Chronic fatigue syndrome in patient with ALK-positive anaplastic large cell lymphoma

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Research Article 
dx.doi.org/10.18081/2333-5106/016-4/75-80
American Journal of BioMedicine Volume 8, Issue 1, pages 13-20
Received November 30, 2019; Accepted December 15, 2019; Published January 11, 2020

Stephen B. Larsen 1, Christian M. Junghanss 1, Angela, Bo Hye Kim 2, Patrick B. Schnell 1

Abstract

Anaplastic large cell lymphoma (ALCL) is a rare type of NHL, and more common subtypes of T-cell lymphoma, we report a case of ALK-positive anaplastic large cell lymphoma preceded by long history of chronic fatigue syndrome. A 75-year-old patient recently developed cervical lymphadenopathy, pyrexia, weight loss, night sweats. Chest computed tomography scan showed widening of the superior mediastinum. Magnetic resonance imaging of the spine demonstrated spinal effacement at T7 raising the risk of cord compression. A lymph node biopsy showed positive anaplastic large cell lymphoma. Patient was treated with standard first-line chemotherapy proceed to the autologous stem cell transplantation.

Keywords: ALK; NHL; Cervical Lymphadenopathy

Copyright © 2020 by Schnell et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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References

1. Chang CM, Warren JL, Engels EA. Chronic fatigue syndrome and subsequent risk of cancer among elderly US adults. Cancer 2012;118(23):5929-36. [PubMed]

2. Fluge Ø, Risa K, Lunde S, et al. B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment. PLoS One  2015;10(7):e0129898. [PubMed]

3. Savage KJ, Harris NL, Vose JM, et al. International Peripheral T-Cell Lymphoma Project. ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project. Blood 2008;111(12):5496-504. [PubMed]

4. Varghese GM, Trowbridge P, Doherty T. Investigating and managing pyrexia of unknown origin in adults. BMJ 2010;341:C5470. [PubMed]

5. Srikantharajah M, Mahendra P, Vydianath B, et al. Kikuchi-Fujimoto disease: a rare but important differential diagnosis for lymphadenopathy. BMJ Case Rep 2014;2014. [PubMed]

6. Zeller B, Loge JH, Kanellopoulos A, et al. Chronic fatigue in long-term survivors of childhood lymphomas and leukemia: persistence and associated clinical factors. J Pediatr Hematol Oncol 2014;36(6):438-44. [PubMed]

7. Levine PH, Peterson D, McNamee FL, et al. Does chronic fatigue syndrome predispose to non-Hodgkin's lymphoma? Cancer Res 1992;52(19 Suppl):5516s-5518s. [PubMed]

8. Grufferman, S, Eby NL, Huang M, et al. Epidemiologie investigations of an outbreak of chronic fatigue immune dysfunction syndrome in a defined population. Am. J. Epidemici 1988;12ft:898.

9. Bradley AS, Ford B, Bansal AS. Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls. Clin Exp Immunol 2013;172(1):73-80. [PubMed]

10. Dearden CE, Johnson R, Pettengell R, et al. British Committee for Standards in Haematology. Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma). Br J Haematol 201;153(4):451-85. [PubMed]

11. Hsu C, Woodgett J, Huang TH, et al. CIP2A overexpression up-regulates Akt signaling pathway in metastasis breast cancer cell. American Journal of BioMedicine 2015;3(10):658-673. [Abstract/Full-Text]

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