Response of children with short stature to recombinant human growth hormone (rhGH) after the first year of therapy

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Rajaa Jabbar kadhum¹*

∗Correspondence author: ¹Pediatric Department, Faculty of medicine, Kufa university

Abstract

Short stature is the commonest cause of referral to a pediatric endocrine unit. The primary goal of rhGH therapy is attaining normal adult height. The objective of this study is to determine the response of children with short stature to rhGH after one year of therapy. The study were done on 110 children with short stature, their age range was 3-14 years they received regular rhGH in a dose of 0.24-0.3 mg/kg/week and their response were followed during the first year of therapy by bone age, anthropometric measurements & height velocity. Growth hormone deficiency was the leading cause of short stature contributing to 84.5%. There was significant increase in mean height velocity after one year of rhGH therapy (7.1±3.5cm per year) which is almost the double of pretreatment height velocity. The catch up growth was slow in the first 6 months of therapy and there was significant increase in bone age at the end of the first year. The lowest response in mean height velocity was in prepubertal children 3-5 years of age (1.54±0.44 cm per year). We conclude that the growth was slow during the first six months but there was significant growth at the end of the first year of therapy with doubling of the height velocity & significant increase in bone age. The response was slow in the prepubertal age.

Keywords: Response; Short stature; rhGH; Height measurements; Height velocity

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