Month: August 2018

SARM1mediates TLR9-induced vascular hyperpermeability following hemorrhagic shock

Research Article   Received March 14, 2018; Accepted July 29, 2018; Published August 30, 2018 http://dx.doi.org/10.18081/2333-5106/015-10/644-657 Morrison R. Doelle 1, Benjamin M. Predmore, Adrienne A. Kiss, Henri A. Leuvenink, Robert Clements  Abstract After hemorrhagic shock, vascular endothelial cell (EC) injury is the primary cause of microcirculatory disturbance. SARM1 plays an important role in the process of microcirculatory […]

Cardioprotective role of trans retinoic acid in trastuzumab-induced cardiotoxicity through modulation of Erk2 signalling pathway

Research Article   Received February 28, 2018; Accepted July 27, 2018; Published August 22, 2018 http://dx.doi.org/10.18081/2333-5106/015-10/631-643 Jun Fan 1, Cheng Yang 1, Dong-Qing Chin 2, Alexis Romanos 1, Eva Wang 1, Monica M. Vargas 1, Hao Cheng 1 Abstract Breast cancer is the most frequent cancer in women, and it is increasingly identified in younger women. The involvement […]

Potential effects of gender disparity in downregulation of AKT after post-cerebral ischemia and reperfusion

Research Article   Received February 22, 2018; Accepted July 10, 2018; Published August 12, 2018 http://dx.doi.org/10.18081/2333-5106/015-10/619-630 John M. Morrisona, Claire B. Gibson, Zhan Wang, Daniel H. Klionsky Abstract Sex-dependent differences exist in stroke susceptibility, prevalence, severity, and response to treatment in humans. It is well documented that age, sex, and hormonal fluctuations alter not only the course […]