doi: 10.18081/2333-5106/015-07/392-402
Mark B McKenna, Kaisa K Zaman, Patrick K Becker, Thomas H Terraz, Maurizio Q Fracchiolla
Abstract
The objective of this study is to investigate the effects and mechanism of grape seeds extract on Hodgkin lymphoma patients treated with chemotherapy. In vitro study; used a commercially available grape seed extract and exposed Hodgkin cells to 10 µg/mL, 20 µg/mL, and 40 µg/mL concentrations of the extract for 6 and 12 hours. While in vivo study; a total of 47 patients with Hodgkin lymphoma were divided into two groups: the chemotherapy/radiation alone group (21 patients) and the grape seeds extract + chemotherapy/radiation group (26 patients), for 120-day treatment. This study demonstrated that the grape seeds extract had a strong effect on the CDK inhibitor which controls the cell cycle and had an adjuvant effect on Hodgkin patients treated with chemotherapy.
Keywords: Grape seeds; Hodgkin lymphoma; CDK inhibitor; Cell cycle
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