IFN-γ-promote innate defense against gonococcal infection via producing B cells


doi: 10.18081/2333-5106/015-05/295-312 
American Journal of BioMedicine Volume 3, Issue 5, pages 295-312
Published: 27 May 2015

Yan Tsuchimoto; Rong Hwang; Song Chen; Xiang Liu


Gonorrhea is the second most commonly reported bacterial STD. The majority of urethral infections caused by N. gonorrhoeae among men produce symptoms that cause them to seek curative treatment soon enough to prevent serious sequelae, but treatment might not be soon enough to prevent transmission to others. Among women, gonococcal infections might not produce recognizable symptoms until complications have occurred. PID can result in tubal scarring that can lead to infertility or ectopic pregnancy. We investigated an inducible B cell subpopulation that is significantly expanded and produces high levels of IFN-γ during the pathogen infection of gonorrhea. The identification of subpopulation of innate B cells may contribute to a better understanding the role B cell in immune regulation.

Kewords: Gonorrhea; IFN-γ; Innate B cells; Pathogen 

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