IL-37/IL-18Rα complex: receptors, signaling and pathogenesis of diseases




The interleukin 1 (IL-1) family, a subset of cytokines consisting of IL-1a and IL-1b, in addition, seven novel IL-1 family members have been identified based on their sequence homology, three-dimensional protein structure, gene location and receptor binding profile. These proteins are now termed IL-36Ra, IL-36a, IL-36b, IL-36g, IL-37, IL-38 and IL-33 (previously known as IL-1F5, IL-1F6, IL-1F8, IL-1F9, IL-1F7, IL-1F10 and IL-1F11, respectively). Its plays crucial roles in host defense mechanism and in the development of inflammatory diseases. Although IL-17A is the signature cytokine produced by T helper 17 (Th17) cells, IL-17A and other IL-17 family cytokines have multiple sources ranging from immune cells to non-immune cells. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NFκB, MAPKs and C/EBPs to induce the expression of anti-microbial peptides, cytokines and chemokines. The proximal adaptor Act1 is a common mediator during the signaling of all IL-17 cytokines so far and is thus involved in IL-17 mediated host defense and IL-17-driven autoimmune conditions. This review will give an overview and recent updates on the IL-37/IL-18Rα complex, the activation and regulation of IL-37 signaling as well as diseases associated with this cytokine family.

Key words: IL-37; MAPKs; C/EBPs; IL-17; IL-18Rα

Copyright © 2014 by The American Society for BioMedicine and BM-Publisher, Inc.

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Review Article
American Journal of BioMedicine Volume 2, Issue 2, pages 98-105
Received 03 January 2014; accepted 05, April 2014, Published May 30, 2014

How to cite this article
Schultz C, Morin A, Greig DV. MIL-37/IL-18Rα complex: receptors, signaling and pathogenesis of diseases. American Journal of BioMedicine 2014;2(2):98-105.

Case report outline
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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