Research Article
American Journal of BioMedicine
Volume 11, Issue 4, 2023, Pages 165-171 
10.18081/2333-5106/2023.11/165
Libo Han 1 
, Ri Li 1 , Xia Wang * 
Received 23 May 2023; revised 04 August 2023; accepted 06 September 2023; published 21 October 2023
Abstract
Lung cancer has been the most common type of cancer worldwide for several decades. 55 patients treated for lung cancer with a mean age of 60.9±4.2 evaluated through Health-related QoL (HRQoL) were assessed individually using the valid and reliable questionnaires Cancer Quality of Life EORTC (QLQ) - C30 and QLQ - H&N35. The functioning scale in the QLQ-C30 questionnaire with the lowest average score was global health status. The mean QLQ-C30 summary score (77.17 ± 11.4). The symptoms with the highest scores were dyspnea, weight loss, and muscle atrophy. Linear regression analysis demonstrated that Global health status score was associated with education level [β-coefficient = 15.21 (95% CI: 10.2-21.9, P=0.01], alcohol consumption [β-coefficient=11.02 (95% CI: 5.3-16.3), P=0.01]. In conclusion. This study demonstrated several predictors of worse perception of HRQoL through study. Moreover, these predictors should be the focus of preventive measurements, early detection of lung cancer, and target therapy.
Keywords: Lung cancer; QLQ-C30; QLQ - H&N35
Copyright © 2023 Wang, et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cited by other articlesReferencesStatistics
The citation data is computed by the following citation measuring services:Google Scholar
Cited by CrossRef (0)
Cited by Scopus ()
Cited by CrossRef (0)
Cited by Scopus ()
| 1. Walters S. Benitez-Majano S. Muller P, et al. Is England closing the international gap in cancer survival? Br J Cancer. 2015; 113:848-60. https://doi.org/10.1038/bjc.2015.265 |
||||
| 2. Tanvetyanon T. Robinson LA. Schell MJ, et al. Outcomes of adrenalectomy for isolated synchronous versus metachronous adrenal metastases in non-small-cell lung cancer: a systematic review and pooled analysis. J Clin Oncol. 2008; 26:1142-7. https://doi.org/10.1200/JCO.2007.14.2091 |
||||
| 3. Office for National Statistics Cancer survival by stage at diagnosis for England (experimental statistics): Adults diagnosed 2012, 2013 and 2014 and followed up to 2015. 2016. ONS. | ||||
| 4. Falcoz PE. Puyraveau M. Thomas PA, et al. Video-assisted thoracoscopic surgery versus open lobectomy for primary non-small-cell lung cancer: a propensity-matched analysis of outcome from the European Society of Thoracic Surgeon database. Eur J Cardiothorac Surg. 2016; 49:602-9. https://doi.org/10.1093/ejcts/ezv154 |
||||
| 5. Riaz SP. Linklater KM. Page R, et al. Recent trends in resection rates among non-small cell lung cancer patients in England. Thorax. 2012; 67:811-14. https://doi.org/10.1136/thoraxjnl-2012-201768 |
||||
| 6. Ferrell BR. Temel JS. Temin S, et al. Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2017; 35:96-112. https://doi.org/10.1200/JCO.2016.70.1474 |
||||
| 7. Cancer Research UK. Lung cancer diagnosis and treatment statistics. Cancer Research UK, 2016. | ||||
| 8. O'Dowd EL, McKeever TM, Baldwin DR, et al. What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK? Thorax. 2015; 70:161-8. https://doi.org/10.1136/thoraxjnl-2014-205692 |
||||
| 9. Goldstraw P, Chansky K, Crowley J, et al. The IASLC Lung Cancer Staging Project: Proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016; 11:39-51. https://doi.org/10.1016/j.jtho.2015.09.009 |
||||
| 10. Fayers PM, Aaronson NK, Bjordal K, et al. The EORTC QLQ-C30 Scoring Manual (3rdEdi-tion). European Organisation for Research and Treatment of Cancer, Brussels 2001. | ||||
| 11. Husson O, de Rooij BH, Kieffer J, et al. The EORTC QLQ-C30 Summary Score as Prognostic Factor for Survival of Patients with Cancer in the "Real-World": Results from the Population-Based PROFILES Registry. Oncologist. 2020; 25(4):e722-e732. https://doi.org/10.1634/theoncologist.2019-0348 |
||||
| 12. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Re-search and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1998; 85(5): 365-76. https://doi.org/10.1093/jnci/85.5.365 |
||||
| 13. Chua IS, Zachariah F, Dale W, et al. Early integrated telehealth versus in-person palliative care for patients with advanced lung cancer: A study protocol. J Palliat Med. 2019; 22:S-7. https://doi.org/10.1089/jpm.2019.0210 |
||||
| 14. Cella DF, Bonomi AE, Lloyd SR, et al. Reliability and validity of the functional assessment of cancer therapy-lung (FACT-L) quality of life instrument. Lung Cancer. 1995; 12:199-220. https://doi.org/10.1016/0169-5002(95)00450-F |
||||
| 15. Dharma-Wardene M, Au H-J, Hanson J, et al. Baseline FACT-G score is a predictor of survival for advanced lung cancer. Qual Life Res. 2004; 13:1209-1216. https://doi.org/10.1023/B:QURE.0000037481.36604.eb |
||||
| 16. Eton DT, Cella D, Yost KJ, et al. A combination of distribution- and anchor-based approaches determined minimally important differences (MIDs) for four endpoints in a breast cancer scale. J Clin Epidemiol. 2004; 57:898-910. https://doi.org/10.1016/j.jclinepi.2004.01.012 |
||||
| 17. Kroenke K, Spitzer RL, and Williams JBW: The PHQ-9. J Gen Intern Med. 2001; 16:606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x |
||||
| 18. Dionne-Odom JN, Hull JG, Martin MY, et al. Associations between advanced cancer patients' survival and family caregiver presence and burden. Cancer Med. 2016; 5:853-862. https://doi.org/10.1002/cam4.653 |
||||
| 19. Courtin E and Knapp M. Social isolation, loneliness and health in old age: A scoping review. Health Soc Care Commun. 2017; 25:799-812. https://doi.org/10.1111/hsc.12311 |
||||
| 20. Holt-Lunstad J, Smith TB, Baker M, et al. Loneliness and social isolation as risk factors for mortality: A meta-analytic review. Perspect Psychol Sci. 2015; 10:227-237. https://doi.org/10.1177/1745691614568352 |
||||
| 21. Helgeson VS. Social support and quality of life. Qual Life Res. 2003; 12(Suppl 1):25-31. https://doi.org/10.1023/A:1023509117524 |
||||
| 22. Katschnig H, Freeman H, Sartorius N. Quality of Life in Mental Disorders. 2nd edn New York: Wiley, 2005. https://doi.org/10.1345/aph.1G684 |
||||
| 23. Mohammed GK, Mohammed SM, Hadi NR, et al. Association between Natural Killer Cell Cytotoxicity and the Progression of Non-Small Cell Lung Cancer. Sys Rev Pharm. 2020; 11(4): 543-551. https://doi.org/10.31838/srp.2020.4.81 |
||||
| 24. Hsu YH, Chai HY, Lin YF, et al. Health-related quality of life and satisfaction with case management in cancer survivors. J Clin Nurs. 2017; 26:4597-604. https://doi.org/10.1111/jocn.13805 |
||||
| 25. Pergolotti M, Deal AM, Williams GR, et al. Activities, function, and health-related quality of life (HRQOL) of older adults with cancer. J Geriatr Oncol. 2017; 8:249-54. https://doi.org/10.1016/j.jgo.2017.02.009 |
||||
| 26. McCarberg BH, Nicholson BD, Todd KH, et al. The impact of pain on quality of life and the unmet needs of pain management: results from pain sufferers and physicians participating in an Internet survey. Am J Ther. 2008; 15:312-20. https://doi.org/10.1097/MJT.0b013e31818164f2 |
||||
| 27. Salomaa ER, Sällinen S, Hiekkanen H, et al. Delays in the diagnosis and treatment of lung cancer. Chest. 2005; 128:2282-8. https://doi.org/10.1378/chest.128.4.2282 |
||||
| 28. Montazeri A, Hole DJ, Milroy R, et al. Quality of life in lung cancer patients: does socioeconomic status matter? Health Qual Life Outcomes. 2003; 1:19. https://doi.org/10.1186/1477-7525-1-19 |
||||
| 29. Myrdal G, Valtysdottir S, Lambe M, et al. Quality of life following lung cancer surgery. Thorax. 2003; 58:194-7. https://doi.org/10.1136/thorax.58.3.194 |
||||
| 30. Lee LJ, Chung CW, Chang YY, et al. Comparison of the quality of life between patients with non-small-cell lung cancer and healthy controls. Qual Life Res. 2011; 20:415-23. https://doi.org/10.1007/s11136-010-9761-y |
||||
| 31. Xia P, Li N, Hau KT, et al. Quality of life of Chinese urban community residents: a psychometric study of the mainland Chinese version of the WHOQOL-BREF. BMC Med Res Methodol. 2012; 12:37. https://doi.org/10.1186/1471-2288-12-37 |
||||
| 32. Lencioni R. Crocetti L. Cioni R, et al. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study) Lancet Oncol. 2008; 9:621-8. https://doi.org/10.1016/S1470-2045(08)70155-4 |
||||
| 33. Felip E, Sakai H, Patel J, et al. OA12.01 Phase II data for the MET inhibitor tepotinib in patients with advanced NSCLC and MET exon 14-skipping mutations. J Thorac Oncol. 2018; 13(10):S347. https://doi.org/10.1016/j.jtho.2018.08.299 |
||||
| 34. Hadi N, Lee J, Adrienne J, et al. Expression of IL-32 modulates NF-κB and p38 MAP kinase pathways in human esophageal cancer. Cytokine. 2014; 61(1):223-227. https://doi.org/10.1016/j.cyto.2012.09.022 |
||||
File and statistics
Permissions
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in American Journal of BioMedicine are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.