Tag: Hedgehog

Hedgehog signaling pathway for advanced ovarian cancer: cross-talk mTOR/AKT kinase

  Yingying YangÂč, Yujie Han, Yongbo Zuo, Dandan Wang, Lina Huang, Jing Ben, Ning Lu∗     Abstract Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. Hedgehog (Hh) signaling plays important roles in embryonic development and in tumor formation. Hh ligands promote the phosphorylation and activation of mTOR […]