Martyn D. Lewis, John P. McKew¹, Kathleen E. Neuzi, Takashi Akasaka* Abstract Highly selective, potent inhibitors of the Src kinase paradigm are helping to unravel the functional importance of individual Src kinase isoforms, coupled with the development of new chemical probes designed for this purpose. Myocardial ischemia/reperfusion (I/R) remains an immediate therapeutic target. Inhibition […]
Tag: ischemia and reperfusion
TAK-242 attenuates renal ischemia and reperfusion injury by inhibiting TLR4 signaling pathway
Research Article dx.doi.org/10.18081/2333-5106/015-12/769-779 Volume 7, Issue 1, pages 1-11 Received July 22, 2018; Accepted December 09, 2018; Published January 07, 2019 Tamas Wilsona, Stefan A. Wieland, Mark Matsunaga, ShuJun Zhang 1 Abstract TAK-242 (resatorvid), a small-molecule–specific inhibitor of Toll-like receptor (TLR) 4 signaling, has been demonstrated to protect renal against IR injury. The […]