Montelukast effects on lymphocyte in asthmatic children

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Faraidwn H. Mustafa1,  Nidhal Abudul Kahder Salem2, Shaswar Ali Mohamad3, Estabraq AR. Al-Wasiti4*

Abstract

Asthma is a common disease in children with grief consequences on social and educational performance of sufferer. Montelueukas has been a mainstay drug for asthma attack controller medication. However, its effect on blood is not well defined. The main objective is to determine the effect of the drug on white blood cells. This case control study encompasses 72 children with confirmed asthma, 36 of them received 4mg of monteleukast granule daily for four months, the remaining half did not receive the drug. Complete Blood Count (CBC) was performed at the   beginning of the study and then monthly till the end of the study. There was no statistically significant difference in the CBC parameters at beginning and during the first two months (P>0.5) between the two group. There was a trend toward a reduction in the lymphocyte count in the treated group in the third month in comparison to the control one. The last CBC measurement (4 months) showed statistically significant reduction in the lymphocyte count (P<0.01) in the treated group when compared to the control group. In conclusion: Monteleukast negatively influence the number of lymphocytes and caution should be exercised to avoid prescribing the drug in conditions known to reduce lymphocyte counts such as Covid-19 infection.

Keywords: Montelukast; Lymphocyte; Asthmatic children; Covid-19

Copyright © 2021 by The American Society for BioMedicine and BM-Publisher, Inc.

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Research Article
http://dx.doi.org/10.18081/2333-5106/021-2/145-155
American Journal of BioMedicine Volume 9, Issue 2, pages 145-155
Received February 12, 2021; revised May 30, 2021; accepted June 05, 2021; published July 11, 2021

How to cite this article
Mustafa FH, Salem NA, Mohamad SA, Al-Wasiti ER. Montelukast effects on lymphocyte in asthmatic children. American Journal of BioMedicine 2021;9(2):145-155.
Research Article
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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