Notch signaling in pathogenesis of diseases

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Christense M Erard 1, Carolan B Santos 1, 2, Smith G Tracey 1
Author Affiliations
∗Correspondence author e-mail:smitht@gmail.com: 1,2American Cancer Society Intramural Research, Atlanta, Georgia. 2Department of Medicine, Cancer Institute, Assam, India

 

 

Abstract

The Notch signaling pathway functions on cell fate decisions in a variety of different organizations in multicellular organisms, such as the hematopoietic system, nervous system, vascular system, skin and pancreas. In the majority of cases, Notch signaling blocks cell differentiation towards a primary process, and instead, direct them to a second differentiation. Altering the differentiation program or forcing it to remain in the undifferentiated state, there are several human diseases linked to defects in genes involved in Notch signaling, aberrant Notch signaling has been observed in a number of human cancers, suggesting a possible role of Notch signaling in tumor formation. Further, Recent study demonstrated an essential role for Notch1 in the corneal epithelial barrier recovery after wounding. We systematically searched the electronic PubMed database for research articles about Notch gene polymorphisms and diseases up to October 2013. Revman 5.0 software was adopted to conduct the meta-analysis. Crude odds ratio (ORs) and 95% confidence intervals (95% CIs) were calculated by either fixed-effects model or random-effects model. The present meta-analysis suggests that Notch gene polymorphisms are associated with the susceptibility of many diseases especially cancer.
Keywords: Notch; Pathogenesis; Cancer; Signaling pathway; Crude odds ratio

Copyright © 2020 by The American Society for BioMedicine and BM-Publisher, Inc.

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Research Article

DOI: http://dx.doi.org/10.18081/ajbm/2333-5106-013-12/19-22
American Journal of BioMedicine Volume 2, Issue 1, pages 1-22
Received 12 October 2013; accepted January 5, 2014, Published February 20, 2014

How to cite this article
Erard CM, Santos CB, Tracey SG. Notch signaling in pathogenesis of diseases. American Journal of BioMedicine 2014;2(1):1-22.

Case report outline
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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