The Notch signaling pathway functions on cell fate decisions in a variety of different organizations in multicellular organisms, such as the hematopoietic system, nervous system, vascular system, skin and pancreas. In the majority of cases, Notch signaling blocks cell differentiation towards a primary process, and instead, direct them to a second differentiation. Altering the differentiation program or forcing it to remain in the undifferentiated state, there are several human diseases linked to defects in genes involved in Notch signaling, aberrant Notch signaling has been observed in a number of human cancers, suggesting a possible role of Notch signaling in tumor formation. Further, Recent study demonstrated an essential role for Notch1 in the corneal epithelial barrier recovery after wounding. We systematically searched the electronic PubMed database for research articles about Notch gene polymorphisms and diseases up to October 2013. Revman 5.0 software was adopted to conduct the meta-analysis. Crude odds ratio (ORs) and 95% confidence intervals (95% CIs) were calculated by either fixed-effects model or random-effects model. The present meta-analysis suggests that Notch gene polymorphisms are associated with the susceptibility of many diseases especially cancer.
Keywords: Notch; Pathogenesis; Cancer; Signaling pathway; Crude odds ratio
Copyright © 2020 by The American Society for BioMedicine and BM-Publisher, Inc.
- Mizutani K, Yoon K, Dang L, Tokunaga A, Gaiano N. Differential Notch signalling distinguishes neural stem cells from intermediate progenitors. Nature 2007;449:351–355. [PubMed/NCBI]
- Blank U, Karlsson G, Karlsson S. Signaling pathways governing stem-cell fate. Blood 2008;111:492–503. [PubMed/NCBI]
- Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009;137:216–233. [Google Scholar]
- Kurpinski K, Lam H, Chu J, et al. Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. Stem Cells 2010;28:734–742. [PubMed/NCBI]
- NG Yousif, M Al-Matwari. Overexpression of Notch-1 induced tamoxifen resistance through down regulation of ESR1 in positive estrogen receptor breast cancer. Journal of clinical oncology 2012;30(15). [Google Scholar]
- Hofmann JJ, Iruela-Arispe ML. Notch signaling in blood vessels: who is talking to whom about what? Circ Res 2007;100:1556–1568. [PubMed/NCBI]
- Piggott K, Deng J, Warrington K, et al. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Circulation 2011;123: 309–318. [PubMed/NCBI]
- Hatakeyama J, Kageyama R. Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent hes genes in the developing nervous system. Cereb Cortex 2006;16:132–137. [PubMed/NCBI]
- Muskavitch MAT. Delta-Notch signalling and drosophila cell fate choice. Dev Biol 2009;166:415–430. [PubMed/NCBI]
- Nagarsheth MH, Viehman A, Lippa SM, Lippa CF. Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease. J Neurol Sci 2006;244:111–116.
- Kageyama R, Ohtsuka T, Shimojo H, Imayoshi. Dynamic regulation of Notch signalling in neural progenitor cells. Curr Opin Cell Biol 2009;21:733–740.
- Agrawal S, Archer C, Schaffer DV. Computational models of the Notch network elucidate mechanisms of context-dependent signalling. PLoS Comput Biol 2009;5(5):e1000390.
- Fior R, Henrique D. A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. Dev Biol 2005;281:318–333.
- Chen H, Thiagalingam A, Chopra H, et al. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci USA 1999;94:5355–5360.
- Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signalling: cell fate control and signal integration in development. Science 1999;284:770–776. [PubMed/NCBI]
- NG Yousif, J Kamiran, MG Yousif, S Anderson, J Albaghdadi. Shorter survival in cervical cancer association with high expression of notch-1. Annals of oncology 2012;23:327-328. [Google Scholar]
- Radtke F,Wilson A, Mancini SJ, MacDonald HR. NOTCH regulation of lymphocyte development and function. Nat Immunol 2004;5:247–253. [PubMed/NCBI]
- Artavanis-Tsakonas S, Rand MD, Lake RJ. NOTCH signaling: cell fate control and signal integration in development. Science 1999;284:770–776. [PubMed/NCBI]
- Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different NOTCH ligands on antigen-presenting cells. Cell 2004;117:515–526. [CrossRef]
- Elyaman W, Bradshaw EM, Wang Y, et al. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J Immunol 2007;179:5990–5998.
- Reizis B, Leder P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev 2002;16:295-300. [Abstract/FREE Full Text]
- Kuroda K, Han H, Tani S, et al. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 2003;18:301-312. [CrossRef]
- Yamaguchi E, Chiba S, Kumano K, et al. Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice. Immunol. Lett 2002;81:59-64. [CrossRef]
- NG Yousif, L Ao, DA Fullerton, X Meng. Myocardial tissue TLR4-mediated MCP-1 production contributes to the mechanisms of myocardial injury following cold ischemia and reperfusion. SHOCK 2012;35:65. [Google Scholar]
- Vigouroux S, Yvon E, Wagner HJ, et al. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J. Virol. 2003;77:10872-10880. [Abstract/FREE Full Text]
- Genoud S, Lappe-Siefke C, Goebbels S, et al. Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol 2002;158:709–18. [Abstract/FREE Full Text]
- Higuchi M, Kiyama H, Hayakawa T, Hamada Y, Tsujimoto Y. Differential expression of Notch1 and Notch2 in developing and adult mouse brain. Brain Res Mol Brain Res 1995;29:263–72. [Medline]
- Huppert SS, Le A, Schroeter EH, et al. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 2000;405:966–70. [Medline]
- Lardelli M, Williams R, Lendahl U. Notch-related genes in animal development. Int J Dev Biol 1995;39:769–80. [Medline]
- Lindsell CE, Boulter J, diSibio G, Gossler A, Weinmaster G. Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development. Mol Cell Neurosci 1996;8:14–27. [Medline]
- Shawber C, Boulter J, Lindsell CE, Weinmaster G. Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev Biol 1996;180:370–6. [CrossRef]
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American Journal of BioMedicine Volume 2, Issue 1, pages 1-13
Received 12 October 2013; accepted January 5, 2014, Published February 20, 2014
How to cite this article
Erard CM, Santos CB, Tracey SG. Notch signaling in pathogenesis of diseases. American Journal of BioMedicine 2014;2(1):1-4.
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