Month: February 2014

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Adhesion molecule expression trigger immune-mediated pathology in lupus-nephritis

Bassim Jens Boldron 1, Simon Caltabiano 1, Steven D. Debono 1, 2, Robert Thompson 1, Malcolm Scammells 1, Robert Westover 1, Ye Wu 1, 3, Philip Frugier *2    Abstract Doxorubicin (Dox) is one of the most potent broad-spectrum antitumor anthracycline antibiotics, its use is limited by the development of life-threatening cardiomyopathy. Doxorubicin generates free radicals and induces oxidative stress associated with cellular […]

Notch signaling in pathogenesis of diseases

Christense M Erard 1, Carolan B Santos 1, 2, Smith G Tracey 1     Abstract The Notch signaling pathway functions on cell fate decisions in a variety of different organizations in multicellular organisms, such as the hematopoietic system, nervous system, vascular system, skin and pancreas. In the majority of cases, Notch signaling blocks cell differentiation towards a primary […]

Ghrelin reduces myocardial injury following global ischemia and reperfusion via suppression of myocardial inflammatory response

Everett W. Austin, Nasser Ghaly Yousif, Lihua Ao, Joseph C. Cleveland, David A. Fullerton, Xianzhong Meng¹* Abstract Ghrelin is a small endogenous peptide principally produced and secreted by the gastric mucosa, with a major role in appetite and metabolism regulation. We hypothesized that anti-inflammatory therapy, as produced by exogenous administration of ghrelin, would decrease the […]