Rong Zhang 1, Steven Singh, Xiang Ha, George Cowsik, Oleg Lavezzi, Hiroshi Caudell, Roschelle Ohura* Abstract Cardiovascular dysfunction is a major consequence of septic shock and contributes to the high morbidity and mortality of sepsis. Groups of proteins that comprise the Toll or Toll-like family of receptors detect the pathogen and mount a rapid […]
Month: June 2014
Role of monocyte chemoattractant protein-1 (MCP-1) in atherosclerosis: Signature of monocytes and macrophages
Daniel Ramote 1, Jacks Kishony, Leibler Bren* Abstract The monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the C-C chemokine family, and a potent chemotactic factor for monocytes. MCP-1 is believed to be identical to JE, a gene whose expression is induced in mouse fibroblasts by platelet-derived growth factor. Two SNPs of CCL2, […]
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The additive effect of TGF-ß with TNF-α on type VII collagen gene expression to activate the expression of an extracellular matrix-related gene
Susan De Curtis 1, Stephen Aderaye 1, Jonathan Bower 2, Catharina Grulich 2, Jennifer Hollox 2, Sabin Scheetz 2 Abstract Type VII collagen is the predominant, if not the exclusive, component of the anchoring fibrils, attachment structures stabilizing the association of the cutaneous basement membrane to the underlying dermis. In the skin, type VII […]
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