Role of monocyte chemoattractant protein-1 (MCP-1) in atherosclerosis: Signature of monocytes and macrophages




The monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the C-C chemokine family, and a potent chemotactic factor for monocytes. MCP-1 is believed to be identical to JE, a gene whose expression is induced in mouse fibroblasts by platelet-derived growth factor. Two SNPs of CCL2, namely, G-927C and A-2578G, were found to be associated with carotid intima-media thickness, which reflects generalized atherosclerosis and is predictive of future vascular events. Monocyte chemoattractant protein-1 (MCP-1) is the first discovered and most extensively studied CC chemokine, and the amount of studies on its role in the etiologies of atherosclerosis-related diseases have increased exponentially during recent years. This review attempted to provide a perspective of the history, regulatory mechanisms, functions, and therapeutic strategies of this chemokine. The highlights of this review include the roles of MCP-1 in the development of atherosclerosis, cardiovascular diseases, and dyslipidemia. Therapie

Key words: MCP-1; Atherosclerosis; Monocyte; Macrophage; Proinflammatory cytokines

Copyright © 2014 by The American Society for BioMedicine and BM-Publisher, Inc.

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Review Article
American Journal of BioMedicine 2014, Volume 2, Issue 2, pages 116-124
Received 30 January 2013; accepted May 11, 2014, Published June 22, 2014

How to cite this article
Ramote D, Kishony J, Bren J. Role of monocyte chemoattractant protein-1 (MCP-1) in atherosclerosis: Signature of monocytes and macrophages. American Journal of BioMedicine 2014;2(2):11-124.

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3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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