"Research Article" American Journal of BioMedicine  Volume 3, Issue 3, pages 134-140, March 2015 Delbert N.Thota; Anna Oddis; Gurpreet Banerjee; Hiroshi Caudell, Roschelle Ohura Abstract Toll-like receptor 4 (TLR4), as a membrane surface receptor for bacterial, fungal, viral and certain endogenous substances, has been described to contribute to the development of sepsis. Wild-type mice […]

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. However, it is also a fundamental step in the transition of tumors from a benign state to a malignant one, leading to the use of angiogenesis inhibitorsin the treatment of cancer. Mechanical stimulation of angiogenesis is not well characterized. There is a significant amount of controversy with regard to shear stress acting on capillaries to cause angiogenesis. This may be due to an increase in the production of nitric oxide during exercise. Nitric oxide results in vasodilation of blood vessels. While, Chemical stimulation of angiogenesis is performed by various angiogenic proteins, including several growth factors. The purposes of this topic are to review the pathophysiologic angiogenesis process and examine the clinical applications of antiangiogenic therapy in the prevention and treatment of diseases.

    doi: 10.18081/ajbm/2333-5106/014-03/122-133 "Research Article" American Journal of BioMedicine  Volume 3, Issue 3, pages 122-133, March 2015 Tsan Chao; Chi Ming Yang; Po-Chieh Guo; Chiung-Wen Han; Huei Chen Abstract Matrix metalloproteinases (MMPs) have been regarded as major critical molecules assisting tumor cells during metastasis. From the earliest work on MMPs in cancer, there has […]

  "Research Article" American Journal of BioMedicine  Volume 3, Issue 3, pages 111-121, March 2015 Zaid Yousif Hameed Shukur Abstract Epibulbar dermoids are the most common episcleral choristomas, these lesions may present unilaterally or bilaterally, and the majority (85%) are located in regions of the bulbar conjunctiva, limbus, cornea, and/or caruncles.  An 11 months old […]