Hedgehog signaling pathway for advanced ovarian cancer: cross-talk mTOR/AKT kinase

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Yingying Yang¹, Yujie Han, Yongbo Zuo, Dandan Wang, Lina Huang, Jing Ben, Ning Lu∗

   
Abstract
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. Hedgehog (Hh) signaling plays important roles in embryonic development and in tumor formation. Hh ligands promote the phosphorylation and activation of mTOR and AKT kinases, yet the molecular mechanism underlying these processes are unknown. In the present study, we assessed the effects of Hh on human Ovarian cancer cells, and discussed Hh inhibition therapeutic mechanism involving hedgehog signaling-related proteins. This study provides an experimental basis for a better understanding of Res molecular mechanisms, better treatment outcomes, and increases survival rates as an anticancer agent. Hh signaling induces activation of the mTOR/AKT kinase signaling arm, resulting in up-regulation of human ovarian cancer cells. We concluded that targeting the hedgehog pathway offers a novel treatment approach for advance ovarian cancer.

Keywords: Ovarian cancer; Hedgehog; mTOR; AKT kinase

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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DOI: 10.18081/2333-5106/016-11/505-512

Cited by in Scopus

Research Article
American Journal of BioMedicine Volume 4, Issue 11, pages 505-512
Received June 01, 2016; accepted October 30, 2016; published November 28, 2016

How to cite this article
Yang Y, Han Y, Zuo Y, et al. Hedgehog signaling pathway for advanced ovarian cancer: cross-talk mTOR/AKT kinase. American Journal of BioMedicine 2016;4(11):505-512.

Article outline
1. Abstract
2. Keywords
3. Introduction
4. Materials and Methods
5. Results
6. Discussions
7. Acknowledgements
8. References