Inhibin A level in the detection of preeclampsia and its severity

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Basima Sh. Alghazali¹

   
Abstract
Preeclampsia (PE), a human-pregnancy-specific disease defined as the occurrence of hypertension and significant protein urea in a previously healthy woman on or after the 20th week of gestation, although its main etiology is still unknown many biochemical markers have been studded one of them is serum inhibin A. Aim of the study is to evaluate the association of maternal serum levels of inhibin A in pregnancy complicated by preeclampsia and compare it with normal non preeclamptic pregnancy and to study its usefulness in the detection of its severity. Prospective case control study of maternal human inhibin A level in pregnant women with preeclampsia in comparison with the control group in Al- Zahra Maternity Teaching Hospital. The women included in this study were divided into two groups, 50 control group who are normotensive and 50 preeclamptic patient which further divided into mild and sever. In each group cardiovascular, renal connective tissue diseases were excluded. A complete clinical history was taken from each women including; maternal age, parity, gestational age, and blood sample was taken for biochemical and hematological investigation. The blood samples were sent for liver function test, renal function test, complete blood picture and Inhibin A level. The level of inhibin A in both forms of preeclampsia, severs and mild is 154.9474±16.45767 and 150.0774±8.21035 respectively, which is significantly higher than normal control group (103.9600±14.76080). Together these data confirmed that the level of inihibin A was greater in preeclampsia than in normal pregnancy which may prove to be clinically useful laboratory markers for detection of preeclampsia.

Keywords: Preeclampsia; Pregnancy; Inhibin A

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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DOI: 10.18081/2333-5106/016-10/435-442

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Research Article
American Journal of BioMedicine Volume 4, Issue 10, pages 435-442
Received June 29, 2016; accepted September 30, 2016; published October 26, 2016

How to cite this article
Alghazali BS. Inhibin A level in the detection of preeclampsia and its severity. American Journal of BioMedicine 2016;4(10):435-442.

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