Abstract
The treatment of severe acute kidney injury with dialytic support for renal replacement therapy can be life sustaining and permit recovery from critical illness. The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and reduced in the corresponding adult tissues. We used used in study C57BL/6, HMG+/− and HMG−/− mice and found that HMG is expressed in the mouse embryonic kidney at the cortex area. HMG knockout led to enhanced Wnt/β-
Keywords: High-mobility-group; Wnt/β-
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Research Article
http://dx.doi.org/10.18081/2333-5106/021-01/123-134
American Journal of BioMedicine Volume 9, Issue 2, pages 154-163
Received March 30, 2021; revised May 25, 2021; accepted June 02, 2021; published June 15, 2021