Critical role of high-mobility-group proteins in kidney development/cross-talk Wnt/β-catenin signaling pathway

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Abstract

The treatment of severe acute kidney injury with dialytic support for renal replacement therapy can be life sustaining and permit recovery from critical illness. The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and reduced in the corresponding adult tissues. We used used in study C57BL/6, HMG+/− and HMG−/−  mice and found that HMG is expressed in the mouse embryonic kidney at the cortex area. HMG knockout led to enhanced Wnt/β-catenin signaling pathway. Analysis of siRNA-mediated loss-of-function experiments in embryonic kidney culture confirmed the role of HMG as a key regulator of cortex epithelium differentiation.

Keywords: High-mobility-group; Wnt/β-catenin; Kidney

Copyright © 2021 by The American Society for BioMedicine and BM-Publisher, Inc.

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Research Article
http://dx.doi.org/10.18081/2333-5106/021-01/123-134
American Journal of BioMedicine Volume 9, Issue 1, pages 123-134
Received November 11, 2020; Accepted January 20, 2021; Published March 22, 2021

How to cite this article
Arndt MS, Wheaton WD, Welch WR, Payen WE. Epidemiology of acute lung injury in patients with cerebrovascular accident: a retrospective study. American Journal of BioMedicine 2021;9(1):123-134.
Research Article
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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