Christophe Shukla, Simon Senkus, Concetta Maceski, Nicola Runza,¹* Abstract Breast cancer is the most common cancer among women and HER2 (human epidermal growth factor receptor 2) is a gene that can play a role in the development of breast cancer. Herceptin (chemical name: trastuzumab), which works against HER2-positive breast cancers by blocking the ability of the cancer cells to […]
Month: January 2019
Critical role of EP2-PKA signaling reduced myocardial function via macrophages activation
Research Article dx.doi.org/10.18081/2333-5106/015-12/780-792 American Journal of BioMedicine Volume 7, Issue 1, pages 12-23 Received July 30, 2018; Accepted December 23, 2018; Published January 19, 2019 Carmen S. Booth, Hashimoto G. Weis, Pablo Hales, Amanda H. Matherly, Lynn C. Graf 1 Abstract Macrophages play critical roles in the promotion of myocardial infarction (MI) and the subsequent impairment […]
TAK-242 attenuates renal ischemia and reperfusion injury by inhibiting TLR4 signaling pathway
Research Article dx.doi.org/10.18081/2333-5106/015-12/769-779 Volume 7, Issue 1, pages 1-11 Received July 22, 2018; Accepted December 09, 2018; Published January 07, 2019 Tamas Wilsona, Stefan A. Wieland, Mark Matsunaga, ShuJun Zhang 1 Abstract TAK-242 (resatorvid), a small-molecule–specific inhibitor of Toll-like receptor (TLR) 4 signaling, has been demonstrated to protect renal against IR injury. The […]