Multivariate analyses of triple-negative breast cancer compare with non-triple-negative breast cancer: A multicenter retrospective study

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American Journal of BioMedicine Volume 10, Issue 1, pages 13-24
Nasser Ghaly Yousif *¹, Emilyn Duarte Conceição ²

Author Affiliations
*Correspondence author e-mail: yousif_ghaly@mu.edu.iq: ¹ Department of Medicine, Al muthanna Medical School, Iraq, ² Instituto de Microbiologia Paulo de Góes, Laboratório de Micobactérias, Brasil.

 

Abstract

Breast cancer is a heterogeneous disease of multiple subtypes with distinct morphologies and clinical implications. Triple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. The purpose of this study is to compare outcome of breast cancer for triple negative versus non-triple negative breast cancer. Population-based retrospective analysis was performed using the Surveillance, Epidemiology, and End Results (SEER) database. Female patients who had breast cancer from 2015 to 2021 were included in two centers and excluded patients’ files with incomplete data. Patients were divided into two group, triple negative breast cancer (TNBC) and non-TNBC. Clinical outcome, stages, types of treatment and its adverse events were compared. Also, and overall survival was calculated. A total of 105 patients with TNBC and 566 with non-TNBC were included in this retrospective study. The multivariate analysis showed that the tumor size and nodal involvement were independent predictors of negative events. While age at presentation, family history, grade had significant difference (p=0.005). Moreover, the number of locoregional failures, 5-year locoregional recurrence free, and mortalities were not significantly different (p=0.2). In conclusions: Our findings showed that the outcome of triple negative has worse survival than patients with non-TNBC and non-triple negative breast cancers and more aggressive at late stage.

Keywords: Breast cancer; Triple negative breast cancer; Non-triple-negative breast cancer

Copyright © 2022 Conceição ED et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Research Article
    http://dx.doi.org/10.18081/2333-5106/2022.10/13
    American Journal of BioMedicine Volume 10, Issue 1, pages 13-24
    Received November 28, 2021; revised January 19, 2022; accepted February 04, 2022; published February 28, 2022

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    How to cite this article
    Yousif NG, Conceição ED. Multivariate analyses of triple-negative breast cancer compare with non-triple-negative breast cancer: A multicenter retrospective study. American Journal of BioMedicine 2022;10(1):13-24.
    Case Study
    1. Abstract
    2. Introduction
    3. Methods and patients
    4. Results
    5. Discussion
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