Breast cancer immunotherapy and personalized medicine






Review Article

American Journal of BioMedicine
Volume 10, Issue 4, October 21 2022, Pages 146-158 | http://dx.doi.org/10.18081/2333-5106/2022.10/146

Kishwer R Pinsky 1, Emily V Pichard 1, Ahmad J Sahib 1, 2, Andrea F Risch 1*

Author Affiliations
*Correspondence author e-mail: Rischfa@gmail.com : 1 Department of Biological Sciences, Northern Illinois University, USA. 2 Department of Medical Oncology, Cairo University, Egypt.

Received  May 11 2022   Revised  July 30 2022   Accepted  September 22 2022   Published  October 21 2022

 

Abstract

Breast cancer response to immunotherapy is succussed; however, the evaluation of sensitive/resistant target treatment subpopulations based on stratification by tumor biomarkers may improve the predictiveness of response to immunotherapy. Treatment decisions which were based in the past predominantly on the anatomic extent of the disease are shifting to the underlying biological mechanisms. Gene array technology has led to the recognition that breast cancer is a heterogeneous disease composed of different biological subtypes, and genetic profiling enables response to chemotherapy to be predicted. Biological therapy has been developed to target HER2 receptor and combination of antibody drug conjugates linked cytotoxic therapy to HER2 antibodies. This review will give a general overview of the impact of breast cancer and the role of immunotherapy in breast cancer as well as studying tumor biomarkers that increase the likelihood of success with immunotherapy in breast cancer.

Keywords: Breast cancer; Immunotherapy; Sensitive/resistant target treatment

Copyright © 2022 Andrea F Risch, et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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How to cite this article
Pinsky KR, Pichard EV, Sahib AJ, Risch AF. Breast cancer immunotherapy and personalized medicine. American Journal of BioMedicine. 2022; 10(4):146-158

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