Assessment of cervical cytomorphological changes in infertile women undergoing IVF/ICSI

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Ban Jumaa Qasim¹, Estabraq AR. Al wasiti²*mail of corresponding author, Rasha S. Abd-al-fatah³



The aim of this study is to assess cervical cytomormophological changes in cervical smears taken from infertile women undergoing IVF/ICSI compared with normal fertile women. A case-control study of 100 cases were included, 50 infertile group and 50 normal fertile control group both in age range between (20-44), Pap smear taken prior to ova pickup in case group and in preovulatory day in control group. The mean age for case group was 28.9 ±5.6 year; and the mean age of control group was 29.7 ±5.5 years with no significant difference between them t=1.99, p=0.5, the most frequent cause of infertility is polycystic ovaries or with polycystic ovarian syndrome  which diagnosed in (36%) of patients  then (28%) of  patients  diagnosed  with  unexplained infertility. Case group has (22%)  diagnosed with atypical squamous cells with undetermined significance (ASC-US) while control group has just 1 case (2%) with ASC-US and this affects pregnancy test result since (18%) out of  (22%) of patient with (ASC-US) pap smear report  has negative pregnancy test. Statistical analysis shows significant correlation between positive cervicitis and  negative pregnancy test (P value = 0.04) because (52%) out of (66%) with positive cervicitis has negative pregnancy test.beside a significant relation between positive infection in pap smear report  and negative pregnancy test because (30%) out of (34%) with positive infection in pap smear  has negative pregnancy test. In Conclusions, infertile women eligible for IVF are more probable to have ASC-US when compared with normal fertile women, ASC-US worsen pregnancy test results in women undergoing IVF/ICSI  because (18%) out of (22%) of patient with (ASC-US) have negative pregnancy test.

Keywords: IVF/ICSI; Cervical cytomorphological; Cervical cancer

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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DOI: 10.18081/2333-5106/016-9/388-396
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Research Article
American Journal of BioMedicine Volume 4, Issue 9, pages 388-396
Received June 23, 2016; accepted August 30, 2016; published September 25, 2016

How to cite this article
Qasim B, Al wasiti E, Abd-al-fatah RS. Assessment of cervical cytomorphological changes in infertile women undergoing IVF/ICSI. American Journal of BioMedicine 2016;4(9):388-396.

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